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Issues with existing erectile dysfunction treatments.

As well as lifestyle changes dependent on the causes of an individual’s erectile dysfunction, those suffering with erectile dysfunction have access to a range of first line therapies called phosphodiesterase type 5 (PDE5) inhibitors, which include Viagra, as well as Cialis (tadalafil), Levitra (vardenafil) and Spedra (avanafil).

Although these therapies have an approximately 70% success rate, PDE5 inhibitors have to be taken between 30 minutes and two hours before sexual activity leading a lack of spontaneity in the sex lives of those taking the drugs. Viagra, Levitra and Spedra are also negatively affected by food, and it is recommended to avoid consuming alcohol when taking any of the four drugs.

These issues were noted by Professor David Ralph, consultant urologist at University College London and trustee of the SAA, during an R&D discussion event organised by Futura Medical earlier this month. Second line therapies for erectile dysfunction include alprostadil injections; two branded examples are Caverject and Viridal. For these therapies, aprostadil, which is the same chemical produced by an erect penis, is injected into the shaft of the penis to help blood flow.

Ralph noted this treatment can cause scarring to patient’s penises; the SAA also states it can be very painful. There are other therapies where alprostadil in pellet form is administered into the urethra, however, Ralph comments that efficacy is not as good as the injectable form.

A third line of therapy for severe cases are penile prosthesis and surgical removal of the prostates. Moving towards the ideal treatment for erectile dysfunction.

Since oral agents introduced in the 1990s are the most recent major innovation in the erectile dysfunction field, there is a lot of patient expectation for more high-quality treatment options.

In his presentation, Ralph described the ideal treatment for erectile dysfunction as having good evidence of efficacy, having rapid onset, being safe, cheap and discrete, being a localised therapy, not online viagra sales affected by food and drink and acceptable to the patient’s sexual partner.

Using its expertise in transdermal delivery, Futura Medical has developed online viagra sales a topical gel product, called MED2005, using its DermaSys technology to treat mild and moderate erectile dysfunction, which it believes ticks most of these boxes. MED2005 builds upon recent developments in creating creams for erectile dysfunction. An example is Takeda’s Vitaros, a topical cream formulation of alprostadil, which incorporates a skin-permeation enhancer that aids absorption after application to the meatus of the penis.

Futura Medical’s topical gel enables the targeted and rapid delivery of glyceryl trinitrate (GTN), a drug originally developed to treat angina, into the glans penis. Phase I and II trials showed that MED2005 was

efficacious

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The company also noted that in

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The ongoing European Phase III trial aims to evaluate the efficacy of the drug, as well as focusing more closely on measuring time of onset and duration of action by using a range of parameters.

Futura Medical is optimistic about the outcome of this trial; it expects results to be published at the end of 2019 and for regulatory filings to follow in the second half of 2020. Clean Room Doors, Emergency Escape Panels, Vision Panels, Hygienic Lift Trolleys, Air and Water Showers. Cold Chain Refrigerated and Freezer ISO Container Systems.

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IQVIA Remote Detailing to Maintain Individualised Engagements with Customers. Abiogen Pharma is a well-established pharmaceutical company headquartered just outside of Pisa, Italy, that develops and markets medical solutions in primary care and rare diseases across international markets. Erectile dysfunction is the inability to achieve or maintain an erection of the penis during sexual activity. Erectile dysfunction (ED), sometimes called impotence, is a common symptom for men with MS.

Although there are drugs that can help with the physical symptom, effective treatment involves looking at psychological and emotional factors that may be contributing. There are a number of possible causes for erectile dysfunction in men with multiple sclerosis. Arousal and erection require a complicated interaction of nerve messages.

When MS damages these nerve pathways, messages from the brain can be delayed or blocked meaning that the erection doesn't last long or, in some cases, may not occur at all. Several MS symptoms can make it difficult to get or keep an erection. If you have pain or numbness in the genital area, potentially pleasurable sensations can become uncomfortable. Depression or reduced attention span or concentration can lead to distraction.

For example worry that sexual activity will cause spasms or fatigue, or that you might wet the bed or soil yourself.

If MS has dented your self-confidence or self-image, or affected how you think viagra store usa partners see you, this may undermine your ability to enjoy sex and make erections harder to maintain.

Problems with erections are relatively common in the general population and the cause of your symptoms may be unrelated to MS.

Factors that can affect sexual response include: Lifestyle factors, such as drinking too much alcohol, taking drugs, being overweight or smoking.

Other medical conditions, such as heart disease, diabetes, high blood online viagra sales pressure or kidney problems.

Worries, anxiety or stress about other aspects of your life.

Side effects of medication, such as from some online viagra sales anti-depressants or anti-spasticity drugs. Ageing - difficulties with erections are more frequent in older men.

Venous leak - a physical condition in which the extra blood in the penis is not retained during an erection.

The cause of your symptom may involve several factors, some related to MS and others not.

Effective management requires a thorough assessment of all

the

Erectile dysfunction is thought to be more common amongst men with MS and research suggests anything from one quarter to two thirds of men with MS may be affected at some point.

The most important and most powerful starting point for managing sexual issues is a willingness to talk about them.

Although there are treatments available that can restore the ability to achieve an erection, the effective management of the symptom requires an assessment of the whole person.