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The maximum decrease in blood pressure occurred between 1 and 4 hours after dosing.

Trazodone: (Major) Avoid coadministration of vardenafil and trazodone.

Therapeutic (10 mg) and supratherapeutic (80 mg) doses of vardenafil produce an increase in QTc interval (e.g., 4 to 6 msec calculated by individual QT correction).

When vardenafil (10 mg) was given with gatifloxacin (400 mg), an additive effect buy teva sildenafil online on the QT interval was observed. Trazodone can prolong the QT/QTc interval at therapeutic doses. In addition, there are post-marketing reports of torsade de

pointes

Therefore, the manufacturer recommends avoiding trazodone in patients receiving other drugs that increase the QT interval.

Tricyclic antidepressants: (Minor) Use vardenafil with caution in combination with tricyclic antidepressants (TCAs) as concurrent use may increase the risk of QT prolongation.

Tricyclic antidepressants share pharmacologic properties similar to the Class IA antiarrhythmic agents and may prolong the QT interval, particularly in overdose or with

higher-dose

Trifluoperazine: (Minor) Use vardenafil with caution in combination with trifluoperazine as concurrent use may increase the risk of QT prolongation. Trifluoperazine is associated with a possible risk for QT prolongation. Both therapeutic and supratherapeutic doses of vardenafil produce an increase in QTc interval. Triptorelin: (Moderate) Consider whether the benefits of androgen deprivation therapy (i.e., triptorelin) outweigh the potential risks of QT prolongation in patients receiving vardenafil as concurrent use may increase the risk of QT prolongation. Both therapeutic and supratherapeutic doses of vardenafil produce an increase in QTc interval. Androgen deprivation therapy may also prolong the QT/QTc interval.

Vandetanib: (Major) Avoid coadministration of vandetanib with vardenafil due to an increased risk of QT prolongation and torsade de pointes (TdP). If concomitant use is unavoidable, monitor ECGs for QT prolongation and monitor electrolytes; correct hypocalcemia, hypomagnesemia, and/or hypomagnesemia prior to vandetanib administration.

An interruption of vandetanib therapy or dose reduction may be necessary for QT prolongation.

Vandetanib can prolong the QT interval in a concentration-dependent manner; TdP and sudden death have been reported in patients receiving vandetanib.

Both therapeutic and supratherapeutic doses of vardenafil also produce an increase in QTc interval.

Vemurafenib: (Major) Vemurafenib has been associated with QT prolongation. If vemurafenib and another drug, such as vardenafil, that is associated with a possible risk for QT prolongation and torsade de pointes (TdP) must be coadministered, ECG monitoring is recommended; closely monitor the patient for QT interval prolongation.

Also, vardenafil is a CYP3A4 substrate, while vemurafenib is a CYP3A4 substrate/inducer. Therefore concentrations of vardenafil may be decreased with concomitant use.

Venlafaxine: (Moderate) Use vardenafil with caution in combination with venlafaxine due to increased risk of QT prolongation.

Both therapeutic and supratherapeutic doses of vardenafil produce an increase in QTc interval.

Venlafaxine administration is also associated with a possible risk of QT prolongation; torsade de pointes has been reported with postmarketing use. Verapamil: (Moderate) Vardenafil is metabolized by

hepatic

Increased systemic exposure to vardenafil may result in an increase in vardenafil-induced adverse effects. Patients taking moderate CYP3A4 inhibitors, such as verapamil, may need to buy teva sildenafil online have their vardenafil dose decreased to 5 mg PO in a 24-hour period. Antihypertensives, when used with vardenafil, additionally have additive effects on blood pressure. In a clinical pharmacology study of patients with erectile dysfunction,

single

The maximum decrease in blood pressure occurred between 1 and 4 hours after dosing.

Vigabatrin: (Major) Vigabatrin should not be used with phosphodiesterase inhibitors, which is associated with serious ophthalmic effects (e.g., retinopathy or glaucoma) unless the benefit of treatment buy teva sildenafil online clearly outweighs the risks.

Voriconazole: (Major) Caution is advised when administering voriconazole with vardenafil due to the potential for additive effects on the QT interval and increased exposure to vardenafil.

If these drugs must be administered together, consider use of a lower vardenafil dose.

However, because vardenafil orally disintegrating tablets (ODTs) provide increased exposure as compared to the regular tablets, concurrent use of vardenafil ODTs and voriconazole should be avoided.

In addition, because both vardenafil and voriconazole are associated with QT prolongation, coadministration may increase buy teva sildenafil online the risk irregular heartbeats.

If these drugs are given together, closely monitor for prolongation of the QT interval. Rigorous attempts to correct any electrolyte abnormalities (i.e., potassium, magnesium, calcium) should be made before initiating concurrent therapy. Vorinostat: (Moderate) Use vardenafil with caution in combination with vorinostat due to increased risk of QT prolongation. Both therapeutic and supratherapeutic doses of vardenafil produce an increase in QTc interval.

Vorinostat therapy is also associated with a risk of QT prolongation.

Zafirlukast: (Minor) Vardenafil is metabolized by CYP3A4.

Inhibitors of CYP3A4, such as zafirlukast, can reduce vardenafil clearance.

Increased systemic exposure to vardenafil may result in an increase in vardenafil-induced adverse effects. Zileuton: (Minor) Vardenafil is metabolized by CYP3A4. Inhibitors of CYP3A4, such as zileuton, can reduce vardenafil clearance. Increased systemic exposure to vardenafil may result in an increase in vardenafil-induced adverse effects. Ziprasidone: (Major) Concomitant use of ziprasidone and vardenafil should be avoided due to the potential for additive QT prolongation.

Clinical trial data indicate that ziprasidone causes QT prolongation; there are postmarketing reports of torsade de pointes (TdP) in patients with multiple confounding factors. Both therapeutic and supratherapeutic doses of vardenafil produce an increase in QTc interval. There are no adequate and well-controlled trials of vardenafil in humans during pregnancy. In animal reproduction studies, no adverse developmental outcomes were observed during organogenesis at exposures for unbound vardenafil and its major metabolite at 100 and 29 times, respectively, the maximum recommended human dose (MRHD) of 20 buy teva sildenafil online mg.

Vardenafil is not indicated for use in females and is therefore not recommended during breast-feeding.

There is no information on the presence of vardenafil and its major metabolite in human milk, the effects on the breast-fed infant, or

the

Vardenafil is excreted into the milk of lactating rats at concentrations approximately 10-fold greater than found in the plasma; following a single oral dose of 3 mg/kg, 3.3% of the administered dose was excreted into the milk within 24 hours.