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Drug brand name: Cialis Class: Phosphodiesterase-5 inhibitor FDA-approved indication: Erectile dysfunction Approval date: November 21, 2003 Manufacturer: Eli Lilly and Co. Dosing forms: 5 mg, 10 mg, 20 mg Dosing recommendations: Start at 10 mg before anticipated sexual activity.

Maximum recommended dose is 20 mg; maximum dosing frequency is once per day. In a placebo-controlled, 12-week trial, 7 601 men with mildly to severely impaired erectile function received placebo or 5, 10, or 20 mg of vardenafil.

Subjects receiving vardenafil at any dose saw significantly greater improvement in erectile function than did the placebo group.

Percentage of successful united healthcare viagra intercourse ranged between 71% and 74% for the three vardenafil doses.

For the 20-mg dose, 80% of patients experienced improved erections compared with 30% of those taking placebo.

In another trial of 805 men with mild to

severe

ED, 8 vardenafil in 5-mg, 10-mg, and 20-mg doses demonstrated efficacy versus placebo.

Eighty-five percent of men using vardenafil, 20 mg, reported improved erections at 26 weeks compared with 28% in the placebo group. Comparison of clinical trials with sildenafil, vardenafil and tadalafil in erectile dysfunction. 1 The University of Queensland, School of Biomedical Sciences, Australia. Comparison of clinical trials with sildenafil, vardenafil and tadalafil in erectile dysfunction.

Search in PubMed Search in NLM Catalog Add to Search.

1 The University of Queensland, School of Biomedical Sciences, Australia. Erectile dysfunction (ED) affects up to 50% of men, between 40 and 70 years of age.

In the first major trial of

sildenafil

in ED, at 24 weeks, improved erections were reported by 77 and 84% of men taking sildenafil 50 and 100mg, respectively. Subsequently, sildenafil has been reported to be effective in men with ED associated with diabetes and prostate cancer, and in psychogenic ED.

Sildenafil is safe in men with coronary artery disease, provided it is not used with the nitrates (a contraindication).

The most commonly reported adverse effects with sildenafil are headache, flushing and

dyspepsia

.

Vardenafil is more potent and more selective than sildenafil at inhibiting phosphodiesterase-5. Vardenafil is similarly effective to sildenafil in the treatment of ED.

The only advantage that vardenafil has over sildenafil is that it does not inhibit phosphodiesterase-6 to alter colour perception, a rare side effect which sometimes occurs with sildenafil. Tadalafil has a longer duration of action than sildenafil and vardenafil.

Tadalafil is similarly effective as sildenafil in the treatment of ED.

In comparison studies, tadalafil is preferred to sildenafil (50/100mg) by men with ED, possibly because of its longer duration of action. Of the phosphodiesterase inhibitors, tadalafil may displace sildenafil as the drug of choice among men with ED.

Levitra (vardenafil hydrochloride) and Viagra (sildenafil) are erectile dysfunction drugs that work by blocking a certain enzyme (phosphodiesterase-PDE5) used to treat erectile dysfunction (impotence). headache, flushing (warmth or redness in your face, neck, or chest), runny or stuffy nose, stomach upset, heartburn, dizziness, back pain, or nausea.

Call your doctor for medical advice about side effects.

You may report side effects to FDA at 1-800-FDA-1088.

Common side effects of Viagra include: warmth or redness in the face, neck, or chest, stuffy nose, headaches, stomach pain, upset stomach, nausea, diarrhea, memory problems, back pain, an inability to differentiate between the colors green and blue, loss of hearing, ringing in the ears, and dizziness. Levitra is a prescription medicine taken by mouth for the treatment of erectile dysfunction (ED) in men.

ED is a condition where the penis does not harden and expand when a man is sexually excited, or when he cannot keep an erection. A man who has trouble getting or keeping an erection should see his doctor for help if the condition bothers him. Levitra may help a man with ED get and keep an erection when he is sexually excited.

Viagra is a prescription medicine used to treat erectile dysfunction (ED).

You will not get an erection just by taking this medicine.

Viagra

helps

a man with erectile dysfunction get and keep an erection only when he is sexually excited (stimulated).

It is not known if Viagra is safe and effective in women or children under 18 years of age.

Levitra may interact with other medications for erectile dysfunction, conivaptan, imatinib, isoniazid, antidepressants, antibiotics, antifungals, drugs to treat high blood pressure or a prostate disorder, heart or blood pressure medications, or HIV/AIDS medicines.

Viagra may interact with other medications for erectile dysfunction, conivaptan, imatinib, isoniazid, antidepressants, antibiotics, antifungals, drugs to treat high blood pressure or a prostate disorder, heart or blood pressure medications, or HIV/AIDS medicines. Some men can only take a low dose of Levitra because of medical conditions or medicines they take. Your doctor will prescribe the dose that is right for you.

If you are older than 65 or have liver problems, your doctor may start you on a lower dose of Levitra.

If you have prostate problems or high blood pressure, for which you take medicines called alpha-blockers, your doctor may start you on a lower dose of Levitra.

If you are taking certain other medicines your doctor may prescribe a lower starting dose and limit you to one dose of Levitra in a 72-hour (3 days) period. Take 1 Levitra tablet about 1 hour (60 minutes) before sexual activity.

Some form of sexual stimulation is needed for an erection to happen with Levitra. Do not change your dose of Levitra without talking to your doctor.

Your doctor may lower your dose or raise your dose, depending on how your body reacts to Levitra.

Call your doctor or emergency room immediately if you accidentally took more Levitra than prescribed.

Take Viagra exactly as your healthcare provider tells you to take it. Your healthcare provider will tell you how much Viagra to take and when to take it.

Your healthcare provider may change your dose if needed. You may take Viagra between 30 minutes to 4 hours before sexual activity if needed.

If you take Viagra after a high fat meal (such as a cheeseburger and french fries), Viagra may take a little longer to start working Do not take Viagra more than 1 time a day.

If you accidentally take too much Viagra, call your doctor or go to the nearest hospital emergency room right away.

View side-by-side comparisons of medication uses, ratings, cost, side effects, interactions and more.

Levitra Remove Levitra from your drug comparison Staxyn Remove Staxyn from your drug comparison. Levitra may also be used for purposes not listed in this medication guide.

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I am often asked which is the best of the three most common erectile dysfunction treatments: Viagra, Levitra or Cialis. There is no simple answer to this question, as some men find one treatment works better for them than the others. However there are some interesting differences… What is

Viagra

? Viagra is the most well-known of the three as it has been around for over 15 years. This means that a lot is known about its effects and side effects. It works within an hour of taking a tablet, and is best taken on an empty stomach.

The effects of Viagra will last for four to six hours. Viagra was developed and originally marketed by the pharmaceutical company Pfizer, and until 2013 Pfizer was the only company allowed to sell it. When Pfizer’s patent on Viagra expired, the market was open for other companies to produce the medicine, albeit under its generic name Sildenafil, rather than the brand name Viagra.

Sildenafil contains exactly the same active ingredient as Viagra (sildenafil citrate), and works in the same way.

However, because it is the generic version of the medicine, rather than the brand, Sildenafil is considerably cheaper.

Levitra will last for a similar amount of time as Viagra (four to six hours).

The main difference to Viagra is that Levitra tends to be less affected by food or alcohol so can be taken with meals. There is also some evidence that Levitra is more effective in diabetics than other erectile dysfunction medicines.

The effects of

Cialis

(tadalafil) last much longer than those for Viagra or Levitra (up to 36 hours) so many men prefer it as involves less planning. The downside is that if you do experience side effects these can last for longer too.

Like Levitra, Cialis is not affected much by food, so can be taken after a meal.

Different erectile dysfunction medicines suit different people, but it is difficult to tell which one will be best for you until you have tried them all.

While a particular erectile dysfunction medicine may not work for you first time round, we recommend taking it at least eight times before giving up and trying another.

This is because it can often take this long to determine whether or not a medicine is right for you.

We also often suggest that men initially try all three erectile dysfunction medicines to see which is best for them, and we offer a starter pack of Viagra, Levitra and Cialis for those suitable.

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Viagra, Cialis and Levitra have all been shown to be effective in 60-70% of men with erectile dysfunction .

However, as above, it is

possible

that one medicine will be more or

less

effective than the others, and therefore it is best to initially try out all three to see which is best. What are the side effects of Viagra, Cialis and Levitra? All three have similar side effects – headaches, stuffy nose, facial flushing, stomach ache or back pain being the most common.

Some men who have had bad side effects with, say, Viagra will have fewer with Levitra or Cialis, but similarly some find the prolonged side effects of Cialis troubling. Viagra, Cialis and Levitra should not be taken by men who take medicines or recreational drugs containing nitrates.

Cialis should not be taken by men who are on medicines called alpha blockers which are sometimes used to treat prostate problems or high blood pressure.

Men who take alpha blockers can use Viagra or Levitra but must allow at least a six hour gap between taking the alpha blocker and Viagra or Levitra. Viagra, Levitra and Cialis all work in a similar way. They all relax the blood vessels which supply blood to the penis, meaning that more blood can get there when aroused.

These medicines are not aphrodisiacs, so you will still need to be sexually stimulated in order to get an erection. Sildenafil and Spedra are two other major erectile dysfunction medicines which work in a similar way to Viagra, Cialis and Levitra.

As outlined above, Sildenafil is the generic version of Viagra, and contains the same active ingredient.

Out of the five, Spedra is the newest medicine on the market, and takes the shortest amount of time to work – just 15 minutes in some men. If your ED has a psychological cause, such as stress, anxiety or depression, counselling

can

be an effective treatment. This usually takes the form of either couples’ psychosexual counselling, or one-on-one sessions with a psychosexual counsellor.

Sometimes even just talking over the issues with a trained professional can help treat the problem. It can be a while before any effects from counselling are seen, so it is often combined with prescription medicines such as Viagra, Cialis or Levitra which treat ED in the short term.

For more information on these and other treatments for erectile dysfunction, see our medical article Erectile Dysfunction Treatments.

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LEVITRA ® (vardenafil hydrochloride) Tablets, for Oral Use.

LEVITRA (vardenafil hydrochloride) is administered orally for the treatment of erectile dysfunction.

This monohydrochloride salt of vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (

PDE5

).

Vardenafil HCl is designated chemically as piperazine, 1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1- f ][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-, monohydrochloride and has the following structural formula: Vardenafil HCl is a nearly colorless, solid substance with a molecular weight of 579.1 g/mol and a solubility of 0.11 mg/mL in water. LEVITRA is formulated as orange, round, film-coated tablets with “BAYER” cross debossed on one side and “2.5”, “5”, “10”, and “20” on the other side corresponding to 2.5 mg, 5 mg, 10 mg, and 20 mg of vardenafil, respectively. In addition to the active ingredient, vardenafil HCl, each tablet contains microcrystalline cellulose, crospovidone, colloidal silicon dioxide, magnesium stearate, hypromellose, polyethylene glycol, titanium dioxide, yellow ferric oxide, and red ferric oxide. LEVITRA ® is indicated for the treatment of erectile dysfunction. For most patients, the recommended starting dose of LEVITRA is 10 mg, taken orally, as needed, approximately 60 minutes before sexual activity. The dose may be increased to a maximum recommended dose of 20 mg or decreased to 5 mg based on efficacy and side effects. The maximum recommended dosing frequency is once per day. Sexual stimulation is required for a response to treatment.

A starting dose of 5 mg LEVITRA should be considered in patients ? 65 years of age [see Use In Specific Populations ]. For patients with moderate hepatic impairment (Child-Pugh B), a starting dose of 5 mg LEVITRA is recommended. The maximum dose in patients with moderate hepatic impairment should not exceed 10 mg.

Do not use LEVITRA in patients with severe hepatic impairment (Child-Pugh C) [see WARNINGS AND PRECAUTIONS , Use best viagra pills cvs In Specific Populations and CLINICAL PHARMACOLOGY ]. Concomitant use with nitrates and nitric oxide donors in any form is contraindicated [see CONTRAINDICATIONS ].

Guanylate Cyclase (GC) Stimulators, such as riociguat: Concomitant use is contraindicated [see CONTRAINDICATIONS ]. The dosage of LEVITRA may require adjustment in patients receiving potent CYP3A4 inhibitors such as ketoconazole, itraconazole, ritonavir, indinavir, saquinavir, atazanavir, and clarithromycin as well as in other patients receiving moderate CYP3A4 inhibitors such as erythromycin [see DRUG INTERACTIONS ]. For ritonavir, a single dose of 2.5 mg LEVITRA should not be exceeded in a 72-hour period.

For indinavir, saquinavir, atazanavir, ketoconazole 400 mg daily, itraconazole 400 mg daily, and clarithromycin, a single dose of 2.5 mg LEVITRA should not be exceeded in a 24-hour period.

For ketoconazole 200 mg daily, itraconazole 200 mg daily, and erythromycin, a single dose of 5 mg LEVITRA should not be exceeded in a 24-hour period.

In those patients who are stable on alpha-blocker therapy, phosphodiesterase type 5 (PDE5) inhibitors should be initiated at the lowest recommended starting dose.

Concomitant treatment should be initiated only if the patient is stable on his alpha-blocker therapy. Stepwise increase in alpha-blocker dose may be associated with further lowering of blood pressure in patients taking a phosphodiesterase (PDE5) inhibitor including vardenafil. In those patients who are stable on alpha-blocker therapy, LEVITRA should be initiated at a dose of 5 mg (2.5 mg when used concomitantly with certain CYP3A4 inhibitors).

[See WARNINGS AND PRECAUTIONS and DRUG INTERACTIONS .] A time interval between dosing should be considered when Levitra is prescribed concomitantly with alpha-blocker therapy [see CLINICAL PHARMACOLOGY ].

LEVITRA is formulated as orange, round, film-coated tablets with “BAYER” cross debossed on one side and “2.5”, “5”, “10” and “20” on the other side corresponding to 2.5 mg, 5 mg, 10 mg, and 20 mg of vardenafil, respectively. LEVITRA (vardenafil HCl) is formulated as orange, film-coated round tablets with debossed “BAYER” cross on one side and “2.5”, “5”, “10”, and “20” on the other side equivalent to 2.5 mg, 5 mg, 10 mg, and 20 mg of vardenafil, respectively. Package Strength NDC Code Bottles of 30 2.5 mg 0173-0828-13 5 mg 0173-0829-13 10 mg 0173-0830-13 20 mg 0173-0831-13. Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature].

Distributed by: GlaxoSmithKline Research Triangle Park NC 27709.

The following serious adverse reactions with the use of LEVITRA (vardenafil) are discussed elsewhere in the labeling: Cardiovascular Effects [see CONTRAINDICATIONS and WARNINGS AND PRECAUTIONS ] Priapism [see WARNINGS AND PRECAUTIONS ] Effects on Eye [see WARNINGS AND PRECAUTIONS ] Sudden Hearing Loss [see WARNINGS AND PRECAUTIONS ] QT Prolongation [see WARNINGS AND PRECAUTIONS ] Clinical Studies Experience.

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

LEVITRA was administered to over 4430 men (mean age 56, range 18-89 years; 81% White, 6% Black, 2% Asian, 2% Hispanic and 9% Other) during controlled and uncontrolled clinical trials worldwide.

Over 2200 patients were treated for 6 months or longer and 880 patients were treated for at least 1 year.

In placebo-controlled clinical trials, the discontinuation rate due to adverse events was 3.4% for LEVITRA compared to 1.1% for placebo.

When LEVITRA was taken as recommended in placebo-controlled clinical trials, the following adverse reactions were reported (see Table 1).

Table 1: Adverse Reactions Reported By ?2% of Patients Treated with LEVITRA and More Frequent on Drug than Placebo in Fixed and Flexible a Dose Randomized, Controlled Trials of 5 mg, 10 mg, or 20 mg Vardenafil Adverse Reaction Percentage of Patients Reporting Reactions Placebo N = 1199 LEVITRA N = 2203 Headache 4% 15% Flushing 1% 11% Rhinitis 3% 9% Dyspepsia 1% 4% Accidental Injury b 2% 3% Sinusitis 1% 3% Flu Syndrome 2% 3% Dizziness 1% 2% Increased Creatine Kinase 1% 2% Nausea 1% 2% a) Flexible dose studies started all patients at LEVITRA 10 mg and allowed decrease in dose to 5 mg or increase in dose to 20 mg based on side drugstore viagra effects and efficacy. b)

All

the events listed in the above table were deemed to be adverse drug reactions with the exception of accidental injury. Back pain was reported in 2.0% of patients treated with LEVITRA and 1.7% of patients on placebo. Placebo-controlled trials suggested a dose effect in the incidence of some adverse reactions (headache, flushing, dyspepsia, nausea, and rhinitis) over the 5 mg, 10 mg, and 20 mg doses of LEVITRA.

LEVITRA film-coated tablets and vardenafil orally disintegrating tablets have been administered to over 17,000 men (mean age 54.5, range 18.89 years; 70% White, 5% Black, 13% Asian, 4% Hispanic and 8% Other) during controlled and uncontrolled

clinical

trials worldwide. The number of patients treated for 6 months or longer was 3357, and 1350 patients were treated for at least 1 year.

In the placebo-controlled clinical trials for LEVITRA film-coated tablets and vardenafil orally disintegrating tablets, the discontinuation rate due to adverse events was 1.9% for vardenafil compared to 0.8% for placebo. The following section identifies additional, less frequent adverse reactions ( DRUG INTERACTIONS.

Potential For Pharmacodynamic Interactions With LEVITRA. Concomitant use of LEVITRA and nitrates and nitric oxide donors is contraindicated.

The blood pressure lowering effects of sublingual nitrates (0.4 mg) taken 1 and 4 hours after vardenafil and increases in heart rate when taken at 1, 4 and 8 hours after vardenafil were potentiated by a 20 mg dose of LEVITRA in healthy middle-aged subjects. These effects were not observed when LEVITRA 20 mg was taken 24 hours before the nitroglycerin (NTG). Potentiation of the hypotensive effects of nitrates for patients with ischemic heart disease has not been evaluated, and concomitant use of LEVITRA and nitrates is contraindicated [ CONTRAINDICATIONS and CLINICAL PHARMACOLOGY ]. Caution is advised when PDE5 inhibitors are co-administered with alpha-blockers. PDE5 inhibitors, including LEVITRA and alpha-adrenergic blocking agents are both vasodilators with blood-pressure-lowering effects.

When vasodilators are used in combination, an additive effect on blood pressure may be anticipated.

Clinical pharmacology studies have been conducted with co-administration of vardenafil with alfuzosin, terazosin or tamsulosin.

[See DOSAGE AND ADMINISTRATION , WARNINGS AND PRECAUTIONS and CLINICAL PHARMACOLOGY .] Antihypertensives. LEVITRA may add to the blood pressure lowering effects of antihypertensive agents. In a clinical pharmacology study of patients with erectile dysfunction, single doses of vardenafil 20 mg caused a mean maximum decrease in supine blood pressure of 7 mmHg systolic and 8 mmHg diastolic (compared to placebo), accompanied by a mean maximum increase of heart rate of 4 beats per minute. The maximum decrease in blood pressure occurred between 1 and 4 hours after dosing.

Following multiple dosing for 31 days, similar blood pressure responses were observed on Day 31 as on Day 1. LEVITRA (20 mg) did not potentiate the hypotensive effects of alcohol during the 4-hour observation period in healthy volunteers when administered with alcohol (0.5 g/kg body weight, approximately 40 mL of absolute alcohol in a 70 kg person). Alcohol and vardenafil plasma levels were not altered when dosed simultaneously. Studies in human liver microsomes showed that vardenafil is metabolized primarily by cytochrome P450 (CYP) isoforms 3A4/5, and to a lesser degree by CYP2C9. Therefore, inhibitors of these enzymes are expected to reduce vardenafil clearance [see DOSAGE AND ADMINISTRATION and WARNINGS AND PRECAUTIONS ]. Ketoconazole (200 mg once daily) produced a 10-fold increase in vardenafil AUC and a 4-fold increase in maximum concentration (Cmax) when co-administered with LEVITRA (5 mg) in healthy volunteers.

A 5-mg LEVITRA dose should not be exceeded in a 24-hour period when used in combination with 200 mg once daily ketoconazole. Since higher doses of ketoconazole (400 mg daily) may result in higher increases in Cmax and AUC, a single 2.5 mg dose of LEVITRA should not be exceeded in a 24-hour period when used in combination with ketoconazole 400 mg daily.



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