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Vardenafil belongs to a class of drugs called phosphodiesterase type-5 (PDE5) inhibitors. A PDE5 inhibitor stops PDE5 from constricting the arteries. By relaxing the arteries, vardenafil enhances blood flow when a man is sexually aroused. The active ingredient works on the chain of reactions within the penis during arousal. When a male is sexually aroused, nitric oxide is released into his penis, and this buy cialis online visa triggers a chain of reactions. This causes an enzyme, guanylate cyclase, to produce cyclic guanosine monophosphate (cGMP). cGMP regulates the contraction and dilation, or expansion, of blood vessels that carry blood to and from the penis. The chemical reaction causes the vessels that supply the penis to dilate, while those removing blood from the penis contract. Phosphodiesterase-5 (PDE5), another enzyme breaks down or destroys cGMP. When cGMP is destroyed, the blood vessels return to their normal size, effectively ending the erection. Viagra, Cialis, Levitra, and Stendra: Which is best? Viagra, Cialis, Levitra, and Stendra are popular drugs for treating the symptoms of erectile dysfunction. They all have approval from the United States Food and Drug Administration (FDA), and they have the same function, but there are some differences between them. It is important to understand these differences in order to make the best choice about which to choose. Share on Pinterest Cialis and Viagra are PDE5 inhibitors that help to relax the muscles and increase blood flow. Viagra is the brand name for the drug sildenafil, Cialis is the brand name for tadalafil, Levitra is the brand name for vardenafil, and Stendra is the brand name for avanafil. This means they help to relax the muscles and increase blood flow to the body. This makes it easier for blood to get into the penis, and it allows people with erectile dysfunction (ED) to experience a lasting erection during sexual activity. Manufacturers of PDE5 inhibitors recommend taking the pill at least 30 minutes to 1 hour before sexual stimulation, but the timing depends on the drug. How long the effect of each drug lasts is one of the key differences between them: Viagra is a drug that people use only when they need it. A person takes the drug 30 minutes to 1 hour before sexual activity, and the effects typically last for 3-5 hours. Levitra may start working faster than Viagra, but it lasts for about the same amount of time. The effect of a similar dose of Cialis may last up buy cialis online visa to 36 hours. For this reason, people looking for a long-lasting drug may choose Cialis. Depending on the dose, Stendra will be effective after 15–30 minutes, and research shows it is effective for up to 6 hours. Viagra, Cialis, Levitra, and Stendra all come from the same class of chemicals, and they have many similar side effects and interactions. For instance, manufacturers recommend not taking PDE5 inhibitors with grapefruit or grapefruit juice, because the fruit may affect how the drugs work. Nitrates will also interact with these drugs, so people should not use them together. There are some drug-specific side effects to be aware of, however. The side effects include: headaches stomach pain facial flushing congestion nausea or diarrhea color blindness blurred vision. Interactions with Viagra do occur, and it is important for people to be aware of them before choosing a medication for ED. Any drugs for pulmonary hypertension may also interact with Viagra, causing blood pressure to drop to unsafe levels. A recent study in JAMA Internal Medicine has suggested that Viagra could increase the risk of skin cancer. The study found that 3.7 percent of skin cancer cases in men who used the drug sildenafil might have been prevented by not taking it. The side effects include: headaches facial flushing low blood pressure congestion dizziness chest pain. People should not use it with guanylate cyclase stimulators or blood pressure medications, as this combination can trigger an unsafe dip in blood pressure. A person who is taking Cialis and has prostate problems should avoid prescription alpha-blockers, as Cialis serves the buy cialis online visa same function. People should also avoid certain antifungal medications and antibiotics when taking Cialis. Anybody who is considering taking medications such as Cialis for ED should always involve their doctor in the decision. The doctor may ask if the person has a history of any of the following: heart problems stroke liver or kidney problems stomach ulcers abnormal penis shape blood cell problems like sickle cell anemia. All of these conditions may affect the doctor’s decision to prescribe Cialis. The side effects of Levitra include: headache congestion facial flushing indigestion upset stomach dizziness back pain color blindness. If a doctor has told a person to avoid sexual activity due to health problems, they should avoid Levitra. Sexual activity can put extra strain on the heart, especially if it is already weak from heart disease. As with Cialis, a person should not use Levitra with: guanylate cyclase stimulators or blood pressure medications, as these can cause an unsafe dip in blood pressure that can lead to fainting alpha-blockers for prostate problems certain antifungal medications and antibiotics. A doctor may ask a person if they have a history of any of the following: heart problems stroke hearing problems retinitis pigmentosa, an inherited eye condition liver or kidney problems stomach ulcers abnormal penis shape blood cell problems, such as sickle cell anemia. All of these conditions may affect a doctor’s decision to prescribe Levitra. People who are taking drugs to treat an abnormal heartbeat should also avoid taking Levitra. The manufacturers of Stendra claim that it has a low rate of side effects. However, like the other treatments for ED, there is a risk of adverse effects, including: a headache flushing a stuffy or runny nose a sore throat back pain vision problems, including possible sudden vision loss in one or both eyes hearing problems, including a decrease or loss of hearing and tinnitus low blood pressure priapism, an erection that will not go away. A person should seek medical treatment if they experience: vision or hearing loss an erection that does not go away after 4 hours. People should not use Stendra if they have or have had: heart problems or heart surgery pulmonary hypertension low or high blood pressure a deformed penis a stroke severe vision loss bleeding problems a stomach ulcer kidney or liver problems. Anyone with any kind of health condition should speak to a doctor before taking Stendra or any of these medications. A person should not take Stendra with the following drugs: any type of nitrate guanylate cyclase stimulators, such as riociguat (Adempas) HIV protease inhibitors, such as ritonavir (Norvir) some antifungal medication, such as ketoconazole (Nizoral) some antibiotics such as clarithromycin (Biaxin) alpha-blockers and other medications for blood pressure other treatments for ED. People can take Stendra with or without food and with up to three servings of alcohol. It is important not to drink more than three alcoholic drinks, for example, three buy cialis online visa glasses of wine or three measures of whiskey, as this can lead to adverse effects. All four medications may sometimes cause priapism, an erection that will not go away. If a person experiences an erection lasts for more than 4 hours, they should seek medical attention to avoid lasting damage. In rare cases, these drugs can cause serious side effects, including sudden loss of vision in one or both eyes or sudden hearing loss. If a person experiences these symptoms, they should stop taking the drug immediately and call their doctor. I am often asked which is the best of the three most common erectile dysfunction treatments: Viagra, Levitra or Cialis. There is no simple answer to this question, as some men find one treatment works better for them than the others. However there are some interesting differences… What is Viagra? Viagra is the most well-known of the three as it has been around for over 15 years.
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