Amoxil capsule uses

In the present study, application-site disorders were more common in patients treated with the comparator, occurring in 8% of such patients (11 of 137 patients), compared with 0.8% of patients (1 of 132 patients) treated with levofloxacin ( P =.005, by 2-sided Fisher exact test).

Second, the ability to switch directly to oral therapy with the same agent may allow for earlier discharge from the hospital, with corresponding cost savings. Third, levofloxacin kinetics are altered in seriously ill patients.

Statistically significant differences were found in the higher values for maximum plasma concentration and the area under the concentration-time curve noted for patients in the intensive care unit who are administered multiple 500-mg iv doses of levofloxacin, compared with those noted for healthy volunteers; these increased exposures to antimicrobials were not associated with a corresponding increase in adverse events, and, thus, they provide maximum drug effects on problematic pathogens [ 6]. One unexpected finding of the present study was the presence, in respiratory samples, of organisms that are more typically associated with nosocomial pneumonia.

In the patient population studied, it is difficult to determine whether the broader range of organisms, including Enter obacteriaceae and Pseudomonas aeruginosa , contributed to the greater severity of illness or whether the severity of disease and comorbidity affected the range of organisms observed.

The range of pathogens isolated in the present study reinforces the need for continuing careful surveillance of the microbiological etiology of CAP and also reinforces the notion that the antimicrobial agent selected for empirical therapy must be sufficiently broad to include them all.

It is also important to note that the 500-mg daily dose of levofloxacin was used in the present study. Even in this seriously ill population, with its broader range of pathogens, this dose was at least as effective as was the comparator in the treatment of these patients.

In conclusion, levofloxacin was as effective

and

Jonathan Cargan for assistance in preparation of the manuscript. Side Effects What Are Side Effects Associated with Using Amoxicillin? Drug Interactions What Other Drugs Interact with Amoxicillin? Warning and Precautions What Are Warnings and Precautions for Amoxicillin?

Amoxicillin is a prescription antibiotic which is used to treat a wide variety of bacterial infections. It will not work for viral infections (such as common cold, flu).

Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness.

Amoxicillin is also used with other medications to treat stomach/intestinal ulcers caused by the bacteria H. Amoxicillin is available under the following different brand names: Amoxil, Moxatag, and Trimox.

50 mg/5mL 125 mg/5mL 200 mg/5mL 250 mg/5mL 400 mg/5mL.

Dosage Considerations – Should be Given as Follows: Adult Dosage Considerations. 500 mg orally every 12 hours or 250 mg orally every 8 hours for 10-14 days.

875 mg orally every 12 hours or 500 mg orally every 8 hours for 10-14 days. Moxatag: 775 mg orally once per day for 10 days, taken within 1 hour after finishing a meal.

500 mg orally every 12 hours or 250 mg orally every 8 hours. 875 mg orally every 12 hours or 500 mg orally every 8 hours. 500 mg orally every 12 hours or 250 mg orally every 8 hours.

875 mg orally every 12 hours or 500 mg orally every 8 hours. 775 mg (ER tablets) orally once per day for 10 days.

875 mg orally every 12 hours or 500 mg orally every 8 hours for 10-14 days. H pylori infection and active or 1-year history of duodenal ulcer.

1 g orally every 12 hours for 14 days with lansoprazole (30 mg) and clarithromycin (500 mg) 1 g orally every 8 hours for 14 days with lansoprazole (30 mg) in patients intolerant of, or resistant to, clarithromycin.

AHA guidelines recommend prophylaxis only in high-risk patients undergoing invasive procedures who have a history of cardiac conditions that predispose them to a risk of infection. Lyme Disease (Off-label) Chronic migrating rash and other symptoms of early dissemination. 500 mg orally every 8 hours (depending on size of patient) for 3-4 weeks. 50 mg/kg/day every 8 hours in divided doses; maximum 500 mg/dose.

Chlamydial Infection in Pregnant Women (Off-label) First trimester: 500 mg orally every 8 hours for 7 days.

First trimester: Test to document chlamydial eradication and retest for infection 3 months after treatment.

Second or third trimester: Test to document chlamydial eradication. For use when susceptibility test results show susceptibility to amoxicillin, indicating no beta-lactamase production. Renal impairment: Patients with impaired renal function do not generally require dose reduction unless impairment is severe; do not administer extended-release product in patients with creatinine clearance under 30 mL/min.

GFR under 30 mL/min: Should not receive 875 mg (immediate release) or 775 mg (extended release) GFR 10-30 mL/min: 250-500 mg every 12 hours, depending on severity of infection.

GFR under 10 mL/min: 250-500 mg every 24 hours depending on severity of infection. Hemodialysis patients: 250-500 mg every 24 hours, depending on severity of infection; patients should receive additional dose during and at completion of dialysis; do not administer extended-release product or 875 mg immediate release. Pediatric Dosages Considerations: Ear, Nose, and Throat Infections.

Under 3 months: 30 mg/kg/day orally divided every 12 hours for 48-72 hours; for less than 10 days for S pyogenes infections.

Older than 3 months and under 40 kg: 25 mg/kg/day orally divided every 12 hours or 20 mg/kg/day orally divided every 8 hours.

Over 40 kg: 500 mg orally every 12 hours or 250 mg orally every 8 hours for 10-14 days.

Under 3 months: 30 mg/kg/day orally divided every 12 hours for 48-72 hours; for less than 10 days for S pyogenes infections.

Older than 3 months and less than 40 kg: 45 mg/kg/day orally divided every 12 hours or 40 mg/kg/day orally divided every 8 hours. Over 40 kg: 875 mg orally every12 hours or 500 mg orally every 8 hours for 10-14 days. 50 mg/kg orally every day for 10 days, not to exceed 1 g/day, orally 25 mg/kg orally twice daily for 10 days, not to exceed 500 mg/dose.

Older than 12 years: 775 mg (Moxatag) orally once per day for 10 days, taken within 1 hour after meal (swallow tablet whole; do not crush or chew) Acute Otitis Media.

Older than 3 months and under 40kg: 80-90 mg/kg/day orally divided every 8-12 hours. Over 40 kg: 500 mg orally every 12 hours or 250 mg orally every 8 hours for 10-14 days. Under 3 months: greater than or equal to 30 mg/kg/day orally divided every 12 hours for 48-72 hours; for less than 10 days for S pyogenes infections. Older than 3 months and under 40 kg: 45 mg/kg/day orally divided every 12hr or 40 mg/kg/day orally divided every 8 hours.

Over 40kg: 875 mg orally every 12 hours or 500 mg orally every 8 hours for 10-14 days.

pneumoniae is the primary pathogen that causes pneumonia in patients 5-15 years old, a macrolide antibiotic may be a first choice treatment. Under 3 months: Safety and efficacy not established.

Older than 3 months: Empiric treatment: 90 mg/kg/day orally divided every 12 hours for 10 days; not to exceed 4,000 mg/day. Group A Streptococcus: 50-75 mg/kg/day orally divided every 12

hours

pneumoniae (mild infection or step-down therapy or when MICs to penicillin equal to or greater than 2.0 mcg/mL): 90 mg/kg/day orally divided every 12 hours or 45 mg/kg/day divided every 8 hours for 10 days; not to exceed 4,000 mg/day.

Anthrax (Off-label) Post exposure inhalational prophylaxis. Under 40 kg: 15 mg/kg orally every 8 hours (minimum recommended dose; should not be greater than 45 mg/kg/day or given less than every 8 hours.

80 mg/kg/day orally divided every 8 hours for 4 weeks (with simultaneous vaccine) or for 60 days (without vaccine) Infective Endocarditis (Off-label) 50 mg/kg orally 30-60 min before procedure.

AHA guidelines recommend

prophylaxis

conditions

Under 3 months: Safety and efficacy not established.

Over 3 months and 40 kg: 25-50 mg/kg/day divided every 8 hours; not to exceed 500 mg. Mixing oral suspension: Tap bottle until all powder flows freely; add approximately one third of the total amount of water for reconstitution and shake vigorously to wet powder; add remainder of water and shake vigorously again.

After reconstitution, place required amount of suspension directly on child's tongue for swallowing; if taste is unacceptable, required amount of suspension can be added to formula, milk, fruit juice, water, ginger ale, or other cold drinks; preparation must be taken immediately. Shake suspension well before using; any unused portion must be discarded after 14 days. What Are Side Effects Associated with Using Amoxicillin?

Common side effects of amoxicillin include: acuteallergic reaction anemia elevated liverenzymes persistent superficial infections of the skin diarrhea headache nausea vomiting rash antibiotic associated inflammation of the colon serum sickness-like reactions. Post marketing side effects of Amoxicillin reported include: persistent superficial infections of the skin gastrointestinal black hairy tongue hemorrhagic/pseudomembranous colitis (may occur during or after treatment) Hypersensitivity reactions liver dysfunction cholestatic jaundice hepaticcholestasis acute cytolytic hepatitis Renal (crystalluria) Anemia hemolytic anemia Low platelet count (thrombocytopenia) thrombocytopenic purpura eosinophilia Low white blood cell count (leukopenia) agranulocytosis Central nervous system reactions reversible hyperactivity agitation anxiety insomnia confusion convulsions behavioral changes dizziness Tooth discoloration (brown, yellow or gray staining) This document does not contain all possible side effects and others may occur.

Check with your physician for additional information about side effects.

If your doctor has directed you to use this medication for diabetes, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them.

Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Severe Interactions of Amoxicillin include: Amoxicillin has moderate interactions with at least 27 different drugs.

Mild Interactions of Amoxicillin include: amiloride azithromycin aztreonam chloramphenicol clarithromycin erythromycin base erythromycin ethylsuccinate erythromycin lactobionate erythromycin stearate pyridoxine (antidote) This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use.

Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns. Documented hypersensitivity to penicillins, cephalosporins, and imipenem. Do not take Amoxil, Moxatag, or Trimox, if you are allergic to amoxicillin or any ingredients contained in this drug.

In case of overdose, get medical help or contact a Poison Control Center immediately.

See "What Are Side Effects Associated with Using Amoxicillin?" Long-Term Effects.

See "What Are Side Effects Associated with Using Amoxicillin?" Cautions. Severe allergic reaction has been reported rarely but is more likely to occur following parenteral therapy with penicillins.

Clostridium difficile-associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents; severity may range from mild diarrhea to fatal colitis; CDAD may occur over 2 months after discontinuation of therapy; if CDAD is suspected or confirmed, discontinue immediately and begin appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C difficile, and surgical evaluation. Do not administer in patients with infectious mononucleosis or mono because of risk of development of red skin rash. Do not administer to patients in the absence of a proven or suspected bacterial infection because of risk of development of drug-resistant bacteria. Superinfections with bacterial or fungal pathogens may occur during therapy; if suspected, discontinue immediately and begin appropriate treatment. Chewable tablets contain aspartame, which contains phenylalanine.

Use caution in patients with allergy to cephalosporins, carbapenems. Endocarditis prophylaxis: use for only high-risk patients, as per recent AHA guidelines. High doses may cause false urine glucose test by some methods. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. Amoxicillin is a penicillin antibiotic that is used to treat many different types of infection caused by bacteria, such as tonsillitis, bronchitis, pneumonia, and infections of the ear, nose, throat, skin, or urinary tract.

Amoxicillin is also sometimes used together with another antibiotic called clarithromycin (Biaxin) to treat stomach ulcers caused by Helicobacter pylori infection. This combination is sometimes used with a stomach acid reducer called lansoprazole (Prevacid). Amoxicillin may also be used for purposes not listed in this medication guide. Bacterial Endocarditis Prophylaxis Helicobacter pylori Infection Lyme Disease -- Arthritis Lyme Disease -- Carditis Lyme Disease -- Erythema Chronicum Migrans Otitis Media Pneumonia Sinusitis Skin or Soft Tissue Infection Tonsillitis/Pharyngitis Urinary Tract Infection Skin and Structure Infection Bronchitis Chlamydia Infection Lyme Disease Tuberculosis - Urinary Tract Infection - Bacterial/Fungal/Protozoal/Viral Inhalation Bacillus anthracis Cutaneous Bacillus anthracis Anthrax Prophylaxis. What is the most important information I should know about amoxicillin ? You should not use this medicine if you are allergic to any penicillin antibiotic, such as ampicillin, dicloxacillin, oxacillin, penicillin, or ticarcillin.

Tell your doctor if you have ever had: kidney disease; mononucleosis (also called "mono"); diarrhea caused by taking antibiotics; or food or drug allergies (especially to a cephalosporin antibiotic such as Omnicef, Cefzil, Ceftin, Keflex, and others).

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Amoxicillin can make birth control pills less effective. Ask your doctor about using a non-hormonal birth control (condom, diaphragm, cervical cap, or contraceptive sponge) to prevent pregnancy. It may not be safe to breastfeed while using this medicine. The following conditions are contraindicated with this drug.

Check with your physician if you have any of the following: Conditions: diarrhea from an infection with Clostridium difficile bacteria mononucleosis the kissing disease liver problems blockage of normal bile flow severe renal impairment.

Selected from data included with permission and copyrighted by First Databank, Inc.

This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else.

A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

AMOXIL (amoxicillin) Capsules, Tablets, or Powder for Oral Suspension. Formulations of AMOXIL contain amoxicillin, a semisynthetic antibiotic, an analog of ampicillin, with a broad spectrum of bactericidal activity against many Gram-positive and Gram-negative microorganisms. Chemically, it is (2S,5,R,6,R)-6-[(,R)-(-)-2-amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate. It may be represented structurally as: The amoxicillin

molecular

Capsules : Each capsule of AMOXIL, with royal blue opaque cap and pink opaque body, contains 250 mg or 500 mg amoxicillin as the trihydrate. The cap and body of the 250-mg capsule are imprinted with the product name AMOXIL and 250; the cap and body of the 500-mg capsule are imprinted with AMOXIL and 500.

40, gelatin, magnesium stearate, and titanium dioxide.

Tablets : Each tablet contains 500 mg or 875 mg amoxicillin as the trihydrate. Each film-coated, capsule-shaped, pink tablet is debossed with AMOXIL centered over 500 or 875, respectively.