Amoxicillin potassium

Over time, most patients regain their cognitive function. When memory is a problem, consider that this could due to a primary problem with attention or with mood. An individual who can't focus won't be able to remember because he/she didn't "attend" to the item in the first place.

This happens to all of us when we hear someone's name at a party; if we don't focus on the name and perhaps make a mental association to the name to enhance memory storage, we will forget that name within minutes.

Patients with depression often experience problems with memory and verbal fluency; when the depression is resolved, the memory and verbal fluency typically resolve as well.

Rapidly managing pneumonia in older people during a pandemic.

Carl Heneghan, Jeff Aronson, Richard Hobbs, Kamal Mahtani.

Updated 20 th March: This article has been corrected.

Please Check NICE guidance for all prescribing recommendations. (see the end of the amoxicillin trihydrate and clavulanate potassium tablets article for an explanation) 3rd April: NICE guidance updated.

Rationale The current COVID-19 pandemic has highlighted the risk faced by older adults, who are more susceptible to complications, including acute respiratory distress syndrome, usually as a result of pneumonia.

Comorbidities, impaired immunity and frailty, including a reduced ability to cough and to clear secretions from the lungs, can all contribute to this complication.

Older people are therefore more likely to develop severe pneumonia, suffer from respiratory failure, and die. Viruses are thought to cause about 50% of cases of pneumonia. Viral pneumonia is generally less severe than bacterial pneumonia but can act as a precursor to it.

Preventing any pneumonia in older

adults

Identification of the early stages of pneumonia in older patients can prove difficult. Traditional symptoms and signs, including fever, may be absent.

Limited evidence suggests that many tests that are useful in younger patients do not help diagnose infections in older adults. The onset of pneumonia in elderly people can often be rapid, and the prognosis is poor in severe pneumonia: as many as one in five will die.

The older you are, the more prevalent severe pneumonia becomes. Patients in nursing homes appear to fare even worse, as they often have several comorbidities and poor nutritional status and are often physically inactive. [5] In-hospital mortality is significantly higher, even after adjusting for age and sex.

Common causative organisms in elderly people admitted to hospital with pneumonia include Streptococcus pneumoniae and Mycoplasma pneumoniae .

Less commonly, Haemophilus influenzae and Staphylococcus aureus may be responsible.

aureus , Klebsiella pneumoniae , and Pseudomonas aeruginosa are common causative organisms. In community acquired pneumonia, the causative agent is often not known.

Older patients may have polymicrobial infections, which could be a factor in those who do

not

Adhesion of Streptococcus pneumoniae to epithelial cells, for example, is significantly enhanced by human coronavirus HCoV-NL63 infection. Coronavirus causes inflammatory damage in the lungs, preventing clearance of bacteria.

Most deaths in the influenza pandemics of 1918, 1957, and 1968 were caused by secondary bacterial infections. Concurrent bacterial pneumonia was highlighted as a particular problem in elderly people in the 2003 SARS outbreak. Early use of antibiotics in older adults Non-response to initial antimicrobial therapy increases mortality, and so the initial selection of antimicrobials is critical. According to NICE, to cover atypical and multiple pathogens in older patients with pneumonia and at risk of severe

complications

Please note there was an error with the prescribing strategy and this has been corrected as of 20th March – Please Check NICE guidance for all recommendations. ‘ Prescribe oral amoxicillin 500 mg three times a day for 5 days (higher doses can be used — see the BNF) and (if atypical pathogens suspected) oral clarithromycin 500 mg twice a day for 5 days, or oral erythromycin (in pregnancy) 500 mg four times a day for 5 days. Alternatively, if there is a penicillin allergy, or amoxicillin is unsuitable (for example atypical pathogens are suspected) options are oral doxycycline 200 mg on the first day then 100 mg once a day for 4 days (total course of 5 days), or oral clarithromycin 500 mg twice a day for 5 days, or oral erythromycin (in pregnancy) 500 mg four times a day for 5 days.’ The intensity of pneumonia in the community can be assessed using the CRB65 score; each factor scores one point: confusion (abbreviated Mental Test score 8 or less, or new disorientation in person, place, or time); a raised respiratory rate (30 breaths per minute or more); a low blood pressure (diastolic 60 mmHg or less, or systolic less than 90 mmHg); age 65 years or over. Score 1 or 2: intermediate risk (1?10% mortality risk). Score 3 or 4: high risk (more than 10% mortality risk). NICE recommends that anyone with a score of 2 should be admitted to hospital. NICE’s approach, however, doesn’t account for the high risk in very elderly people.

The mortality rate from COVID-19 approaches 15% at age 80 (Figure 1).

Current NICE guidance requires starting antibiotic treatment as soon as possible after establishing a diagnosis of community-acquired pneumonia, and certainly within 4 hours. This strategy is supported by the results of a US multicenter retrospective cohort study, a medical record review of 14,069 patients aged over 65 years and hospitalized with pneumonia. A lower 30-day mortality was associated with antibiotic administration within 8 hours of hospital arrival (odds ratio = 0.85; 95% CI = 0.75-0.96). However, this may not be possible within the constraints of an overstretched service in a pandemic.

If antibiotics have to be taken within 4 hours of onset, there needs to be in place a self-management strategy that permits rapid access to the right antimicrobial treatment. Nursing homes could hold stocks of antibiotics for rapid deployment. Health professional confirmation could then be used to facilitate timely self-prescribing for those most at risk.

Examination strategy The least amount of equipment that is clinically appropriate should be used to assess a patient who might have COVID-19.

This should include a pulse oximeter, a thermometer, and a stethoscope. The ‘eyeball’ test, incorporating information on temperature, oxygen saturation, and pulse rate, should be sufficient to assess severity and cut down significantly on contact time. The absence of any individual chest examination finding has little effect on the probability of diagnosing pneumonia. Assessing blood pressure significantly increases contact time and should be considered only in those in whom it contributes to the decision to admit or not. We recommend documenting that a ‘limited examination’ was performed.

In assessing patients, carry antibiotics in a pre-sealed bag, to cut down entry and exit times from the person’s home or nursing home.

COVID Monitoring Service (CMS) Patients at high risk deemed to be managed at home require monitoring, to ensure that they do not deteriorate. This is essential for nursing homes, where the potential for further spread in their patient population is significant.

Telephone monitoring services can follow up patients to determine whether deterioration occurs, and to detect spread in nursing homes . Based on evolving NHS England guidance we recommend the following pathways.

Category 1: May require admission When it is uncertain that safe care can be provided in the community and the patient is deteriorating.

Clinical pathway: Start antibiotics immediately; discuss management with a designated hospital admitting consultant. Category 2: Home isolation with active health monitoring Higher risk group for severe COVID-19, with stable illness that can be managed in the community.

Clinical pathway: Signs of bacterial pneumonia–start antibiotics; active health monitoring (every other day calls and symptom monitoring) and point of contact if deteriorates. Nursing homes with active cases–daily calls to monitor

individuals

Gov.UK on those at increased risk of severe illness from coronavirus (COVID-19) includes: aged 70 or older (regardless of medical conditions) under 70 with an underlying health condition listed below (ie anyone instructed to get a flu jab as an adult each year on medical grounds): chronic (long-term) respiratory diseases, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema or bronchitis chronic heart disease, such as heart failure chronic kidney disease chronic liver disease, such as hepatitis chronic neurological

conditions

diabetes