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However, as a single 150 mg intravenous dose, fosaprepitant only weakly inhibits CYP3A4 for a duration of 2 days; there is no evidence of CYP3A4 induction.

Fosaprepitant 150 mg IV as a single dose increased the AUC of midazolam (given on days 1 and 4) by approximately 1.8-fold on day 1; there was no effect on day 4. Less than a 2-fold increase in the midazolam AUC is not considered clinically important. Aripiprazole: (Moderate) Use caution when administering aripiprazole with vardenafil due to increased risk of QT prolongation.

Vardenafil is associated with an increase in QTc interval at both therapeutic and supratherapeutic doses. QT prolongation has also occurred during therapeutic use of aripiprazole and following overdose. Arsenic Trioxide: (Major) If possible, drugs that are known to prolong the QT interval should be discontinued prior to initiating arsenic trioxide therapy.

QT prolongation should be expected with the administration of arsenic trioxide.

Torsade de pointes (TdP) and complete atrioventricular block have been cialis price no prescription reported. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with arsenic trioxide include vardenafil.

Therapeutic (10 mg) and supratherapeutic (80 mg) doses of vardenafil produces an increase in QTc interval (e.g., 4 to 6 msec calculated by individual QT correction). Artemether; Lumefantrine: (Major) Concurrent use of vardenafil and artemether; lumefantrine should be avoided due to an increased risk for QT prolongation and torsade de pointes (TdP).

Consider ECG monitoring if vardenafil must be used with or after artemether; lumefantrine treatment.

Administration of artemether; lumefantrine is associated with prolongation of the QT interval. Therapeutic (10 mg) and supratherapeutic (80 mg) doses of vardenafil have also produced increases in QTc interval (e.g., 4 to 6 msec calculated by individual QT correction). Asenapine: (Major) Asenapine has been associated with QT prolongation.

According to the manufacturer of asenapine, the drug should be avoided in combination with other agents also known to have this effect, such as vardenafil.

Therapeutic (10 mg) and supratherapeutic (80 mg) doses of vardenafil produces an increase in QTc interval (e.g., 4 to 6 msec calculated by individual QT correction).

When vardenafil (10 mg) was given with gatifloxacin (400 mg), an additive effect on the QT interval was observed. The effect of vardenafil on the QT interval should be considered when prescribing the drug.

Atazanavir: (Major) Particular caution should be used when prescribing vardenafil to patients receiving atazanavir. Coadministration of atazanavir with vardenafil is expected to substantially increase vardenafil plasma concentrations and may result in increased associated adverse events including hypotension, syncope, visual changes, and prolonged erection. If coadministered, use vardenafil for erectile dysfunction at reduced doses of 2.5 mg, every 24 hours when used with atazanavir or every 72 hours when used with ritonavir-'boosted' atazanavir, with increased monitoring for adverse reactions.

The vardenafil orally disintegrating tablets provide increased exposure as compared to the regular tablets; therefore, do not use the orally disintegrating tablets with moderate or potent CYP3A4 inhibitors, such as atazanavir. Atazanavir; Cobicistat: (Major) Particular caution should be used when prescribing vardenafil to patients receiving atazanavir. Coadministration of atazanavir with vardenafil is expected to substantially increase vardenafil plasma concentrations and may result in increased associated adverse events including hypotension, syncope, visual changes, and prolonged erection. If coadministered, use vardenafil for erectile dysfunction at reduced doses of 2.5 mg, every 24 hours when used with atazanavir or every 72 hours when used with ritonavir-'boosted' atazanavir, with increased monitoring for adverse reactions.

The vardenafil orally disintegrating tablets provide increased exposure as compared to the regular tablets; therefore, do not use the orally disintegrating tablets with moderate or potent CYP3A4 inhibitors, such as atazanavir. (Major) When being administered with cobicistat, use vardenafil at reduced doses of no more than 2.5 mg every 72 hours with increased monitoring for adverse reactions.

Coadministration of vardenafil with cobicistat is expected to substantially increase the plasma concentrations of vardenafil and may result in increased associated adverse events including hypotension, syncope, visual changes, and prolonged erection. Atomoxetine: (Moderate) Consider the potential for additive QT effects if vardenafil is administered with atomoxetine as concurrent use may increase the risk of QT prolongation. QT prolongation has occurred during therapeutic use of atomoxetine and following overdose.

Both therapeutic and supratherapeutic doses of vardenafil produce an increase in QTc interval.

Azithromycin: (Moderate) Due to an increased risk for QT prolongation and torsade de pointes (TdP), caution is advised when administering vardenafil with azithromycin.

Azithromycin has been associated with post-marketing reports of QT prolongation and TdP.

Both therapeutic and supratherapeutic doses of vardenafil produce an increase in QTc interval. Barbiturates: (Minor) Vardenafil is metabolized by cytochrome P450 3A4. It can be expected that concomitant administration of CYP3A4 enzyme-inducers, such as barbiturates, will decrease plasma levels of vardenafil. Bedaquiline: (Major) Due to the potential for QT prolongation and torsade de pointes (TdP), caution is advised when administering bedaquiline with vardenafil.

Bedaquiline has been reported to prolong the QT interval.

Prior to initiating bedaquiline, obtain serum electrolyte concentrations and a baseline ECG.

An ECG should also be performed at least 2, 12, and 24 weeks after starting bedaquiline therapy. Therapeutic (10 mg) and supratherapeutic (80 mg) doses of vardenafil also produce an increase in QTc interval (e.g., 4 to 6 msec calculated by individual QT correction).

Bepridil: (Severe) Concomitant administration of bepridil and vardenafil may cause additive QT prolongation and an increased risk of torsades de pointes (TdP). Bismuth Subcitrate Potassium; Metronidazole; Tetracycline: (Moderate) Consider the potential for additive QT effects if vardenafil is administered with metronidazole.

Both therapeutic and supratherapeutic doses of vardenafil produce an increase in QTc interval.

Potential QT prolongation has been reported in limited case reports with metronidazole.

Both therapeutic and supratherapeutic doses of vardenafil produce an increase in QTc interval.

Bismuth Subsalicylate; Metronidazole; Tetracycline: (Moderate) Consider the potential for additive QT effects if vardenafil is administered with metronidazole. Both therapeutic and supratherapeutic doses of vardenafil produce an increase in QTc interval. Potential QT prolongation has been reported in limited case reports with metronidazole.

Both therapeutic and supratherapeutic doses of vardenafil produce an increase in QTc interval. Boceprevir: (Moderate) Close clinical monitoring is advised when administering vardenafil with boceprevir due to an increased potential for vardenafil-related adverse events, such as hypotension, syncope, visual disturbances, and priapism.

During coadministration, do not exceed a maximum vardenafil dosage of 2.5 mg in 24 hours. If vardenafil dose adjustments are made, re-adjust the dose upon completion of boceprevir treatment. Predictions about the interaction can be made based on the metabolic pathways of vardenafil.

Vardenafil is a substrate of the hepatic isoenzyme CYP3A4; boceprevir inhibits this isoenzyme. When used in combination, the plasma concentrations of vardenafil may be elevated.

Bosentan: (Minor) Vardenafil is metabolized by cytochrome P450 3A4. It can be expected that concomitant administration of bosentan, a CYP3A4 enzyme-inducer, will decrease plasma levels of vardenafil, however, no interaction studies have been performed. Brompheniramine; Carbetapentane; Phenylephrine: (Moderate) The therapeutic effect of phenylephrine may be decreased in patients receiving phosphodiesterase inhibitors.

Monitor patients for decreased pressor effect if these agents are administered concomitantly.

Buprenorphine: (Major) Buprenorphine should be used cautiously and with close monitoring with vardenafil. Buprenorphine has been associated with QT prolongation and has a possible risk of torsade de pointes (TdP). FDA-approved labeling for some buprenorphine products recommend avoiding use with Class 1A and Class III antiarrhythmic medications while other labels recommend avoiding use with any drug that has the potential to prolong the QT interval, such as vardenafil. Therapeutic (10 mg) and supratherapeutic (80 mg) doses of vardenafil produce an increase in QTc interval (e.g., 4 to 6 msec calculated sildenafil dapoxetine tablets online by individual QT correction). When vardenafil (10 mg) was given with gatifloxacin (400 mg), an additive effect on the QT interval was observed.

If these drugs are used together, consider the potential for additive effects on the QT interval.

Buprenorphine; Naloxone: (Major) Buprenorphine should be used buy viagra prescription cautiously and with close monitoring with vardenafil. Buprenorphine has been associated with QT prolongation and has a possible risk of torsade de pointes (TdP).

FDA-approved labeling for some buprenorphine products recommend tab viagra price avoiding use with Class 1A and Class III antiarrhythmic medications while other labels recommend avoiding use with any drug that has the potential to prolong the QT interval, such as vardenafil.

Therapeutic (10 mg) and supratherapeutic (80 mg) doses of vardenafil produce an increase in QTc interval (e.g., 4 to 6 msec calculated by individual QT correction). When vardenafil (10 mg) was given with gatifloxacin (400 mg), an additive

effect

If these drugs are used together, consider the potential for additive effects on the QT interval. Carbamazepine: (Minor) Vardenafil is metabolized by cytochrome P450 3A4. It can be expected that concomitant administration of CYP3A4 enzyme-inducers, such as carbamazepine, will decrease plasma levels of vardenafil, however, no interaction studies have been performed. Carbetapentane; Chlorpheniramine; Phenylephrine: (Moderate) The therapeutic effect of phenylephrine may be decreased in patients receiving phosphodiesterase inhibitors. Monitor patients for decreased pressor effect if these agents are administered concomitantly. Carbetapentane; Diphenhydramine; Phenylephrine: (Moderate) The therapeutic effect of phenylephrine may be decreased in patients receiving phosphodiesterase inhibitors. Monitor patients for decreased pressor effect if these agents are administered concomitantly.

Carbetapentane; Guaifenesin; Phenylephrine: (Moderate) The therapeutic effect of phenylephrine may be decreased in patients receiving phosphodiesterase inhibitors.

Monitor patients for decreased pressor effect if these agents are administered concomitantly.

Carbetapentane; Phenylephrine: (Moderate) The therapeutic effect of phenylephrine may be decreased in patients receiving phosphodiesterase inhibitors. Monitor patients for decreased pressor effect if these agents are administered concomitantly.

Carbetapentane; Phenylephrine; Pyrilamine: (Moderate) The therapeutic effect of phenylephrine may be decreased in patients receiving phosphodiesterase inhibitors.

Monitor patients for decreased pressor effect if these agents are administered concomitantly.

Carbinoxamine; Hydrocodone; Phenylephrine: (Moderate) The therapeutic effect of phenylephrine may be decreased in patients receiving phosphodiesterase inhibitors.

Monitor patients for decreased pressor effect if these agents are administered concomitantly. Carbinoxamine; Phenylephrine: (Moderate) The therapeutic effect of phenylephrine may be decreased in patients receiving phosphodiesterase inhibitors. Monitor patients for decreased pressor effect if these agents are administered concomitantly. Ceritinib: (Major) Due to increased vardenafil exposure, do not use vardenafil orally disintegrating tablets with ceritinib. If possible, avoid concomitant use of vardenafil oral tablets with ceritinib due to the potential for prolongation of the QT interval and increased vardenafil exposure.

If concomitant use of ceritinib and vardenafil oral tablets is unavoidable, decrease the vardenafil dosage and periodically monitor ECGs and electrolytes. Vardenafil is a sensitive CYP3A4 substrate that can produce an increase in QTc interval at both therapeutic and supratherapeutic doses.

Ceritinib is a strong CYP3A4 inhibitor that has been reported to cause concentration-dependent QT prolongation. Coadministration with another strong CYP3A4 inhibitor increased the AUC and Cmax of vardenafil in healthy volunteers by 10-fold and 4-fold, respectively. Chlophedianol; Guaifenesin; Phenylephrine: (Moderate) The therapeutic effect of phenylephrine may be decreased in patients receiving phosphodiesterase inhibitors. Monitor patients for decreased pressor effect if these agents are administered concomitantly. Chloroquine: (Major) Chloroquine administration is associated with an increased risk of QT prolongation and torsades de pointes (TdP). The need to coadminister chloroquine with drugs known to prolong the QT interval should be done with a careful assessment of risks versus benefits and should be avoided when possible.