Sildenafil manufacturer coupon

Even in these cases, however, the nerves will suffer some injury, and it can take 18-24 months or longer for erectile function to return. These men should be treated aggressively with oral or injectable medications for ED in order to speed recovery of the nerves and to prevent muscle wasting in the penis. It should be taken around 60 minutes before sex, but can be taken as much as four hours or as few as 30 minutes before sex. Your doctor will determine the dose that is best for you.

Some men require dose adjustments to find the dose that works best for them.

Men who take sildenafil will not have an erection without sexual stimulation.

This drug is not an aphrodisiac and does not affect libido or desire. Having multiple intercourse sessions with one dose has not been studied. You should not adjust your dose without talking to your provider first.

Men who take nitrates, such as nitroglycerin, Nitro-Bid, Isordil, or Deponit should not take sildenafil. Men who take Cardura, Flomax, or Hytrin for urinary symptoms should not take

sildenafil

This medication can

affect

work

Be sure your provider and pharmacist know all the medication (prescription and over-the-counter) and supplements you sildenafil manufacturer coupon take. Store your medication in the original, labeled container at room temperature and in a dry location (unless otherwise directed by your healthcare provider or pharmacist). This medication should not be stored in a pillbox since it should only be taken prior to sexual activity. Ask your care team where to return any unused medication for disposal. Do not flush down the toilet or throw in the trash. This medication may be covered under your prescription drug plan.

Patient assistance may be available to qualifying individuals without prescription drug coverage through the pharmaceutical company that makes the medication. Your care team can help you find these resources, if they are available.

There are a few side effects experienced with sildenafil. Talk to your doctor, nurse or pharmacist if you have concerns about these side effects. Do not take a higher dose of sildenafil than your provider orders for you. Headache, facial flushing, stuffy or runny sildenafil manufacturer coupon nose, and upset stomach can occur.

Less frequent side effects include blurry vision, a bluish hue to the field of vision, difficulty telling the difference between the colors blue and green, a sensitivity to light, or a sudden loss of vision or hearing. If you experience any of the following while using sildenafil, you should seek immediate medical attention: An erection lasting more than 4 hours. Chest, arm or neck pain, or

nausea

Sudden loss of vision in one or both eyes, loss of hearing, ringing in the ears or dizziness.

Remember, sildenafil does not protect against sexually transmitted diseases, nor does it prevent pregnancy.

Effective birth control is recommended during cancer treatment.

Even if you are not producing sperm, you could still be fertile and conceive. Cardiovascular Effects of the 3 Phosphodiesterase-5 Inhibitors Approved for the Treatment of Erectile Dysfunction.

From the Heart Institute, Good Samaritan Hospital, and the Division of Cardiovascular Medicine, Keck School of Medicine, University of Southern California, Los Angeles.

Within the last year, 2 new phosphodiesterase-5 (PDE5) inhibitors have been approved by the US Food and Drug Administration (FDA) for the treatment of erectile dysfunction (ED). Currently, sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis) are on the market. These agents have been shown to be effective in a broad population of men with ED, including patients

with

1–5 Because the enzyme that they inhibit, sildenafil citrate teva PDE-5, is found in smooth muscle cells of the systemic arteries and veins throughout the body, these agents have mild vasodilator effects and thus, have the potential to impact the cardiovascular system. 6 This fact is especially important for the patient with ED, because risk factors for ED include many of the same risk factors that are associated with coronary artery disease: lipid abnormalities, hypertension, smoking, diabetes, and lack of physical exercise.

7,8 Because erection is a vascular event, endothelial dysfunction may inhibit it. 9 Endothelial dysfunction, an early component of atherosclerosis, is rarely confined to the sildenafil actavis 25 mg arteries supplying blood to the penis but more likely occurs throughout the vascular bed. Kaiser et al 10 studied 30 men with ED and observed that brachial artery flow–mediated vasodilation and nitroglycerin-mediated vasodilation were reduced in these patients

compared

Thus, ED may be an early marker of vascular disease. 10 Patients with frank coronary artery disease, known to be associated with endothelial dysfunction, and frank atherosclerosis often have ED, as we recently observed in 1 study, in which three fourths of the men with chronic stable angina also reported some degree of ED. 11 Hence, the vasodilator effect of these PDE5 agents should be taken into consideration for the cardiac patient, both as a possible concern in some cases or a possible beneficial effect in others.

The purpose of the present review is to sildenafil manufacturer coupon describe the cardiovascular effects of the 3 available PDE5 inhibitors, the issue of nitrate interaction, differences and similarities in labeling regarding concomitant use of nitrates and ?-blockers, their effect on the QT interval, their safety in regard to cardiac events, and sildenafil manufacturer coupon the concept that these agents may eventually play a role in therapies for various cardiac conditions, including pulmonary hypertension and congestive heart failure. Effect of PDE5 Inhibitors on Blood Pressure and Heart Rate. Sildenafil was approved as an effective agent for treating ED in 1998, and its cardiovascular effects have been studied in great depth.

In 1 study of 8 volunteers, 12 80 mg of intravenous sildenafil reduced

systolic

The authors did not observe a significant orthostatic drop in blood pressure or increase in heart rate in the standing position.