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“If the diabetes is controlled after the patient is first diagnosed, then the erections will come back. But if the patient has diabetes for many years, and suddenly decides it’s time to control it, they cannot prevent the damage that’s already been done.” As for treatments, patients with diabetes and related ED should begin with medications like sildenafil and tadalafil, he recommended. But research findings suggest that the drugs will fail in half of men with type 2 diabetes, he said.

Other options include penile self-injections, vacuum devices, and penile implants. The injections “can work well and are painless, but men detest having to inject themselves before sexual activity,” Dr.

And he said men rarely have success using

vacuum

By contrast, penis implants can successfully treat erectile dysfunction in many cases, Dr.

Men trigger erections by squeezing a pump that is implanted into the scrotum.

Fluid then flows from an implanted reservoir into a cylinder implanted in the penis. Men are often pleased by penis implants because they can have sex spontaneously without having to plan for it ahead of time, as required by medications.

Eid receives or has received research support/grants from American Medical Systems, Coloplast, Lilly ICOS, Bayer, Vivus, Pharmacia-Upjohn, and Pfizer. He is or was a consultant and on the speakers bureau for Coloplast, American Medical Systems, Lilly ICOS, Bayer and Pfizer.

How Viagra could boost a widely used blood cancer treatment.

Hematopoietic stem cells can save lives in the treatment of blood cancer, but hurdles remain to

effectively

A research team at the University of California, Santa Cruz has evidence that Pfizer’s popular erectile dysfunction drug Viagra can facilitate the release of stem cells from the bone marrow into the bloodstream, which could ease collection.

Transplantation practitioners traditionally mobilize stem cells using standard granulocyte-colony stimulating factor (G-CSF)—namely, Amgen’s Neupogen (filgrastim).

The UC Santa Cruz team found that pairing Viagra with Sanofi’s stem cell mobilizer Mozobil (plerixafor) worked almost as well in mice, the team reported in the journal Stem Cell Reports. “Given that both drugs are FDA approved, they could be relatively quickly tested in human volunteers,” the study’s senior author, Camilla Forsberg, said in a statement.

If successful, it could provide a new strategy for stem cell transplant preparation, she argued. Even though G-CSF agent works in most donors, it needs to be given for several days before the stem cells can be collected. It’s costly and can cause side effects such as fatigue, nausea and bone pain. The Forsberg lab previously showed that

increasing

So Forsberg and her team hypothesized that Viagra, which relaxes blood vessel walls, might promote stem cell mobilization. After all, sildenafil citrate tablets 200mg price the drug was originally designed to address cardiovascular diseases and is sometimes used to treat pulmonary hypertension. In mice, a single oral dose of Viagra and an injection of Mozobil induced about 2,500 more hematopoietic stem cells to enter the bloodstream within just two hours, representing a 7.5-fold increase compared to control mice.

In contrast, Viagra alone wasn’t effective, and Mozobil monotherapy only showed about a threefold increase.

While three days of Viagra yielded slightly better results, the researchers figured the outcome from just one dose could already rival the performance of Neupogen, which is meant to be given for at least four days.

The researchers went on to transplant the harvested stem cells into other mice.

The animals that received cells resulting from the Viagra-Mozobil combo ended up with superior engraftment of functional, multipotent stem cells than did those given cells from mice that received Mobozil alone, the team reported. Often dubbed “the little blue pill,” Viagra has been available in the U.S. to treat erectile dysfunction for about two decades, and scientists are still finding potential new uses for it.

University of Manchester researchers recently found that Eli Lilly’s Cialis (tadalafil), which belongs to the same PDE5 inhibitor class as Viagra, slowed the progression of heart failure in sheep models.

In a 2018 study published in OncoImmunology, scientists at Ottawa Hospital Research Institute showed a combination of Viagra or Cialis plus Seqirus’ flu vaccine Agriflu could significantly reduce the chance of cancer spread post-surgery in mice.

The PDE5 inhibitors could block myeloid-derived suppressor cells and in turn allow natural killer cells to target metastatic cancer cells, the team found. In recent developments from the Repurposing Drugs in Oncology project, researchers also identified a wide range of mechanisms of action from PDE5 drugs that could be complementary to other drugs in treating cancers, including the notoriously hard-to-treat glioblastoma.

Forsberg and colleagues now plan to work with clinicians to advance their current findings into human studies.

The hope is that Viagra-Mozobil could offer a more affordable alternative to G-CSF.

The simplicity of administration and better safety profile “would likely attract more volunteer donors and make [hematopoietic cell transplantation] a reality for additional patient cohorts,” the authors wrote in the study.

Since March this year, the erectile dysfunction drug Viagra - formerly a prescription-only medicine - has been available to buy over the counter. According to Pfizer, which manufactures the drug, this could benefit the estimated 4.3 million men in the UK who experience erectile problems.

The drug, which has been rebranded as Viagra Connect (sildenafil), works by increasing blood flow to the genitals, which in men results in an erection. First made available in 1998, it has been credited as transforming countless men's sex lives. Perhaps unsurprisingly, it has piqued the curiosity of many women too - if it works so well for their male partners, might it not 'work' for them too? Authored by Abi Millar · Reviewed by Dr Sarah Jarvis MBE. The question was first raised in the New York Times , in an article entitled 'Curious women are seeing if Viagra works wonders for them', just months after Viagra became available. It also made its way into an episode of Sex and the City, in which sexually uninhibited character Samantha uses Viagra to shed her inhibitions further still. Coronavirus: how quickly do COVID-19 symptoms develop and how long do they last?

Coronavirus: what are asymptomatic and mild COVID-19? Coronavirus: what are moderate, severe and critical COVID-19? What are the differences between colds, flu and COVID-19?

Are any coronavirus home remedies safe or effective? However, despite anecdotal reports of its efficacy (the women in the NYT article describe becoming more 'sensitive' and 'receptive'), the drug is still not available for women 20 years on.

You might be able to buy it on behalf of your male partner, if the pharmacist thinks that's appropriate. "Yes there is gentle blood flow improvement - however, that doesn't necessarily equate to sexual enjoyment," says Dr Anand Patel, a GP specialising in sexual problems. "Give Viagra to a man and he's generally pretty happy because his outward sign of arousal is an erection and then he can use that for pleasure.

With a woman, you improve blood flow to the genitals, but there are more factors at play." Mental vs physical arousal.

So why is Viagra not available for women, and what happens to those who take it anyway (against mainstream medical advice)? According to Dr Karen Morton, consultant gynaecologist and founder of Dr Morton's - the medical helpline, the drug should not be viewed as a simple libido enhancer.

"The real reason for men to take Viagra is because they want to have sex and they can’t get or sustain an erection," she says.

"It's easy to see how medication could cause a huge increase in blood supply and hence inflation of the blood vessels which cause the erection. It has nothing to do with 'desire'." She points out that relatively few women are troubled by anything similar.

While women do experience increased genital blood flow during sex, it doesn't follow that female arousal difficulties are related to problems here.

"In women, the main problem is not really being interested in sex with their current (or often any) partner," she says.

"So many women tell me

they

with

These can range from

relationship

"It's a separate mechanism, which allows lubrication in women or blood flow to the penis in men." Is your lifestyle impacting your sex drive? Many people experienced a drop in libido during lockdown and with restrictions still in place, m.

What this means, then, is that a woman could take Viagra without seeing any real effect on her sexual functioning (depending on how this is defined).

All this said, there have been some studies in which female Viagra users have reported an increase in sexual pleasure.

The most famous of these, conducted by the UCLA Female Sexual Medical Center in 2003, involved 202 postmenopausal women with female sexual arousal disorder (FSAD).

(Importantly, none of these women reported emotional difficulties or problems in their relationships.) Over the course of the 12-week trial, participants took either Viagra or a placebo

prior

The evidence base is simply too limited for any real conclusions to be drawn.

On a similar note, we can't say definitively how safe the drug is for women.

While it has been well tolerated in studies, there isn't much information out there about its long-term effects. What we do know for sure is that you shouldn't mix it with certain other drugs.

"It's generally a very safe drug, but if you're opening up blood vessels, that means your blood pressure drops," says Patel. "If you're taking certain other medications that could make your blood pressure drop even further, it could be risky as you could pass out or reduce the blood flow to your heart or brain." Viagra can be particularly dangerous if combined with poppers (amyl nitrate), another drug often used recreationally to enhance sexual sensation.

In rare cases, combining these two drugs has proven fatal.

The

The answer to this, says Morton, will depend on the nature of the problem.

"The most important thing to address is: 'Does it hurt?' There are many gynaecological conditions to consider so get expert advice," she says.

“The majority of postmenopausal women should almost certainly be using oestrogen into the vagina plus good lubrication if they're experiencing vaginal dryness or painful sex." Research suggests that topical oestrogen is generally pretty safe, at least in the short term, but some doctors

may

In these cases, there are many hormone-free vaginal moisturisers and lubricants available that may provide relief. Patel adds that some postmenopausal women may benefit from small amounts of testosterone in addition to hormone replacement therapy (HRT). While this is not generally recommended, owing to limited evidence about its efficacy and concerns about side-effects, he says some doctors will prescribe it 'off licence'.