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There are several classes of antiretrovirals, which are defined by what step of viral replication they target: nucleoside reverse transcriptase inhibitors; non-nucleoside reverse transcriptase inhibitors; protease inhibitors; entry inhibitors; integrase (strand transfer) inhibitors. Usually, having spontaneous erections at night or in the morning is a good indicator of testosterone status.

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Psychological causes of erectile dysfunction in men with HIV.

Your sexual drive or performance can be affected by depression, stress or anxiety, relationship problems, embarrassment or guilt.

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Living with HIV can have a negative impact on your quality of life, social wellbeing and sexual function. Sexual difficulties may have a physical cause, but also be aggravated by psychological and emotional factors, especially in the case of a stigmatised disease such as HIV. Pressure to use condoms could also have an impact upon sexual performance. Some men find that their penis is less sensitive to touch when using condoms, which may contribute to erectile dysfunction. Research has linked sexual dysfunction with less condom use and risky sexual behaviour, possibly for this reason.

"The recreational drug ‘poppers’ should not be used with any erectile dysfunction medications as this could result in a potentially fatal drop in blood pressure." People living with HIV who have sexual dysfunction often also experience anxiety or depression.

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