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Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.This drug may also be used by people with certain heart problems (such as heart valve disease) before medical/dental procedures (such as tooth/gum procedures) to prevent heart infection.

HOW TO USE: Take this medication by mouth with or without food as directed by your doctor, usually every 8 or 12 hours. The dosage is based on your medical condition and response to treatment.Drink plenty of fluids while using this medication unless your doctor tells you otherwise.Antibiotics work best when the amount of medicine in your body is kept at a constant level. Therefore, take this drug at evenly spaced intervals.

To help you remember, take it at the same times each day.Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a return of the infection.Tell your doctor if your condition persists or worsens.

SIDE EFFECTS: Nausea, vomiting, or diarrhea may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.

Many people using this medication do not have serious side effects.Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection (oral or vaginal fungal infection).

Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge or other new symptoms.Tell your doctor immediately if any of these rare but serious side effects occur: dark urine, persistent nausea or vomiting, stomach/abdominal pain, yellowing eyes or skin, easy bruising or bleeding, persistent sore throat or fever.This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped.

Do not use anti-diarrhea products or narcotic pain medications if you have the following symptoms because these products may make them worse. Tell your doctor immediately if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool.A very serious allergic reaction to this drug is rare.

However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.Amoxicillin can commonly cause a mild rash that is usually not serious.

However, you may not be able to tell it apart from a rare rash that could be a sign of a severe allergic reaction. Therefore, get medical help right away if you develop any rash.This is not a complete list of possible side effects.

If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects.

You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects.

You may report side effects to Health Canada at 1-866-234-2345. PRECAUTIONS: Before taking amoxicillin, tell your doctor or pharmacist if you are allergic to it; or to penicillin or cephalosporin antibiotics; or if you have any other allergies.

This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, a certain type of viral infection (infectious mononucleosis).Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).During pregnancy, this medication should be used only when clearly needed.

Discuss the risks and benefits with your doctor.Amoxicillin passes into breast milk.

DRUG INTERACTIONS: The effects of some drugs can change if you take other drugs or herbal products at the same time.

This can increase your risk for serious side effects or may cause your medications not to work correctly.

These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product.

While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.Some products that may interact with this drug include: live bacterial vaccines, methotrexate.Before taking amoxicillin, tell your doctor or pharmacist if you are also taking probenecid. Probenecid slows down the removal of amoxicillin from your body, causing higher levels of this antibiotic in your bloodstream.

For certain types of difficult-to-treat infections, your doctor may prescribe these 2 medications together in order to achieve this effect. Consult your doctor or pharmacist for more details.Although most antibiotics probably do not affect hormonal birth control such as pills,

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Share this list with your doctor and pharmacist to lessen your risk for serious medication problems. OVERDOSE: If overdose is suspected, contact a poison control center or emergency room immediately.

US residents can call their local poison control center at 1-800-222-1222.

Canada residents can call a provincial poison control center.

Symptoms of overdose may include: severe vomiting, persistent diarrhea, a severe decrease in the amount of urine, or seizures.

NOTES: Do not share this medication with others.This medication has been prescribed for your current condition only. Do not use it later for another infection unless your doctor directs you to do so. A different medication may be necessary in that case.With prolonged treatment, laboratory and/or medical tests (such as kidney and liver function, complete

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If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. STORAGE: Store at room temperature according to the product labeling, away from light and moisture. Different brands of this medication have different storage needs.

Check the product package for instructions on how to store your brand, or ask your pharmacist. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

H pylori infection and active or 1-year history of duodenal ulcer. 1 g PO q12hr for 14 days with lansoprazole (30 mg) and clarithromycin (500 mg) Dual therapy. 1 g PO q8hr for 14 days with lansoprazole (30 mg) in patients intolerant of, or resistant to, clarithromycin.

Lyme Disease (Off-label) Erythema migrans and other symptoms of early dissemination. 500 mg PO q8hr (depending on size of patient) for 3-4week.

50 mg/kg/day q8hr in divided doses; maximum 500 mg/dose.

Chlamydial Infection in Pregnant Women (Off-label) First trimester: 500 mg PO q8hr for 7 days.

Mild-to moderate (CrCl ?30 mL/min): No dosage adjustment necessary Severe (CrCl 10-30 mL/min): 250-500 mg q12hr, depending on severity of infection; should not receive 875 mg Severe (CrCl 3 months and >40 kg: 500 mg PO q12hr or 250 mg PO q8hr for 10-14 days.

3 months and >40 kg: 875 mg PO q12hr or 500 mg PO q8hr for 10-14 days.

>40 kg: 500 mg PO q12hr or 250 mg PO q8hr for 10-14 days. 3 months and 40kg: 875 mg PO q12hr or 500 mg PO q8hr for 10-14 days. Pneumonia, community-acquired (Off-label) q8hr q8hr" > >40 kg: 500 mg PO q8hr.

80 mg/kg/day PO divided q8hr for 4 weeks (with concomitant vaccine) or for 60 days (without vaccine) Infective Endocarditis (Off-label) 50 mg/kg PO 30-60 min before procedure.

AHA guidelines recommend prophylaxis only in high-risk patients undergoing invasive procedures with history of cardiac conditions that predispose them to infection. Lyme Disease (Off-label) Erythema migrans and other symptoms of early dissemination.

3 months and 40 kg: 25-50 mg/kg/day divided q8hr; not to exceed 500 mg 3 months and 40 kg: 25-50 mg/kg/day divided q8hr; not to exceed 500 mg" > Interactions. Gastrointestinal (eg, black hairy tongue and hemorrhagic/pseudomembranous colitis, which may occur during or after treatment) Hypersensitivity reactions (eg, anaphylaxis, serum sickness–like reactions, erythematous maculopapular rashes, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, hypersensitivity vasculitis, urticaria) Moderate increase in AST and/or ALT; hepatic dysfunction (eg, cholestatic jaundice, hepatic cholestasis and acute cytolytic hepatitis have been reported) Renal (eg, crystalluria) Anemia (eg, hemolytic anemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leukopenia, agranulocytosis) CNS reactions (eg, reversible hyperactivity, agitation, anxiety, insomnia, confusion, convulsions, behavioral changes, dizziness) Tooth discoloration (brown, yellow, or gray staining); may be reduced or eliminated with brushing or dental cleaning.

Documented hypersensitivity to penicillins, cephalosporins,

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Anaphylaxis has been reported rarely but is more likely to occur following parenteral therapy with penicillins. Clostridium difficile-associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents; severity may range from mild diarrhea to fatal colitis; CDAD may occur over 2 months after discontinuation of therapy; if CDAD is suspected or confirmed, discontinue immediately and begin appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C difficile, and surgical evaluation. Do not administer in patients with infectious mononucleosis because of risk of development of erythematous skin rash.

Do not administer to patients in the absence of a proven or suspected bacterial infection because of risk of development of drug-resistant bacteria.

Superinfections with bacterial or fungal pathogens may occur during therapy; if suspected, discontinue immediately and begin appropriate treatment. Chewable tablets contain aspartame, which contains phenylalanine.

Use caution in patients with allergy to cephalosporins, carbapenems. Endocarditis prophylaxis: use for only high-risk patients, as per recent AHA guidelines.

High doses may cause false urine glucose test by some methods.

Available data from published epidemiologic studies and pharmacovigilance case reports over several decades with amoxicillin use have not established drug-associated risks of major birth defects, miscarriage, or adverse maternal or fetal outcomes. No adverse developmental effects were observed in animal reproduction studies with administration of amoxicillin to pregnant mice and rats at doses up to 12.5 and 25 times the recommended human dose. Data from a published clinical lactation study reports that amoxicillin is present in human milk; published adverse effects with amoxicillin exposure in breastfed infant include diarrhea.

There are no data on effects of amoxicillin on milk production; the developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for therapy and any potential adverse effects on breast-fed child from drug or from underlying maternal condition. Controlled studies in pregnant women show no evidence of fetal risk. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available.

Derivative of ampicillin and has similar antibacterial spectrum (certain gram-positive and gram-negative organisms); similar bactericidal action as penicillin; acts on susceptible bacteria during multiplication stage by inhibiting cell wall mucopeptide biosynthesis; superior bioavailability and stability to gastric acid and has broader spectrum of activity than penicillin; less active than penicillin against Streptococcus pneumococcus; penicillin-resistant strains also resistant to amoxicillin, but higher doses may be effective; more effective against gram-negative organisms (eg, N meningitidis, H influenzae) than penicillin.