Liquid amoxicillin for adults

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Amoxicillin, an analogue of ampicillin, is a semisynthetic antibiotic with essentially the same broad spectrum of bacteriocidal activity as ampicillin against many gram-positive and certain gram-negative microorganisms.

Like ampicillin, this drug is susceptible to destruction by penicillinase.

It is stable in the presence of gastric acid and may be given without regard to meals. amoxicillin trihydrate Amoxil , Polymox , Trimox , Wymox. Pharmacologic classification: aminopenicillin Therapeutic classification: antibiotic Pregnancy risk category B. Available forms Available by prescription only Capsules: 250 mg, 500 mg Pediatric drops: 50 mg/ml (after reconstitution) Suspension: 125 mg/5 ml, 200 mg/5 ml, 250 mg/ 5 ml, 400 mg/5 ml Tablets (chewable): 125 mg, 200 mg, 250 mg, 400 mg Tablets (film-coated): 500 mg, 875 mg. Indications and dosages Systemic infections, acute and chronic urinary or respiratory tract infections caused by susceptible organisms, uncomplicated urinary tract infections caused by susceptible organisms. In adults who have severe infections or those caused by susceptible organisms, 500 mg q 8 hours or 875 mg q 12 hours may be needed.

Pediatric drops Children who weigh less than 6 kg (13 lb): 0.75 ml q 8 hours. Children who weigh 6 to 7 kg (13 to 15 lb): 1 ml q 8 hours. Children who weigh 7 to 8 kg (16 to 18 lb): 1.25 ml q 8 hours.

Children with lower respiratory tract infection who weigh 7 to 8 kg: 2.25 ml q 8 hours. Children with lower respiratory tract infection who weigh 6 to 7 kg: 1.75 ml q 8 hours.

Children with lower respiratory tract infection who weigh less than 6 kg: 1.25 ml q 8 hours. Children older than age 2: 50 mg/kg given with 25 mg/kg probenecid as a single dose. Chlamydial and mycoplasmal infections during pregnancy.

Children: 25 to 50 mg/kg daily (maximum 1 to 2 g daily) P.O.

Acute uncomplicated urinary tract infection in nonpregnant women ?.

In renal failure, patients who require repeated doses may need adjustment of dosing interval.

If creatinine clearance is 10 to 30 ml/minute, increase interval to q 12 hours; if creatinine clearance is less than 10 ml/minute, administer q 24 hours. Supplemental doses may be needed after hemodialysis. Don’t administer 875-mg tablet if creatinine clearance is below 30 ml/minute. Consult current American Heart Association recommendations before administering drug. Postexposure prophylaxis to penicillin-susceptible anthrax.

Children

younger

Spectrum of action of amoxicillin includes non-penicillinase-producing gram-positive bacteria, Streptococcus group B, Neisseria gonorrhoeae, Proteus mirabilis, Salmonella, and Haemophilus influenzae.

It’s also effective against non- penicillinase-producing Staphylococcus aureus, Streptococcus pyogenes, Streptococcus bovis, Streptococcus pneumoniae, Streptococcus viridans, Neisseria meningitidis, Escherichia coli, Salmonella typhi, Bordetella pertussis, Peptococcus, and Peptostreptococcus. Pharmacokinetics Absorption: About 80% absorbed after oral administration. Distribution: Distributed into pleural peritoneal and synovial fluids and into the lungs, prostate, muscle, liver, and gallbladder; it also penetrates middle ear, maxillary sinus and bronchial secretions, tonsils, and sputum. Amoxicillin readily crosses the placental barrier; about 17% to 20% is protein-bound.

Excretion: Excreted mainly in urine by renal tubular secretion and glomerular filtration; also excreted in breast milk.

Elimination half-life in adults is about 1 to 1 1/2 hours; severe renal impairment increases half-life to 7 1/2 hours. Contraindications and precautions Contraindicated in patients hypersensitive to drug or other penicillins. Allopurinol: Increases risk of rash from both drugs.

Hormonal contraceptives: May decrease effectiveness of hormonal contraceptives. Methotrexate: Large doses of penicillins may interfere with renal tubular secretion of methotrexate, thus delaying elimination and prolonging elevated serum methotrexate level. Probenecid: Blocks renal tubular secretion of amoxicillin, raising its serum level.

Khat: May decrease antimicrobial effect of certain penicillins. Discourage khat chewing, or tell patient to take amoxicillin 2 hours after chewing khat. Adverse reactions CNS: lethargy, hallucinations, seizures, anxiety, confusion, agitation, depression, dizziness, fatigue.

GI: nausea, vomiting, diarrhea, glossitis, amoxicillin 375 stomatitis, gastritis, abdominal pain, enterocolitis, pseudomembranous colitis, black "hairy" tongue. GU: interstitial nephritis, nephropathy, vaginitis.

Hematologic: anemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leukopenia, hemolytic anemia, agranulocytosis.

Other: hypersensitivity reactions (erythematous maculopapular rash, urticaria, anaphylaxis ), overgrowth of nonsusceptible organisms. Effects on lab test results ? May increase eosinophil count.

May decrease hemoglobin and granulocyte, platelet, and WBC counts. Overdose and treatment Overdose may cause neuromuscular sensitivity or seizures.

After recent ingestion (4 hours or less), empty the stomach by induced emesis or gastric lavage; follow with activated charcoal to reduce absorption. Special considerations ? Amoxicillin may alter results of urine glucose tests that use cupric sulfate (Benedict’s reagent or Clinitest). Make urine glucose determinations with glucose oxidase methods (Chemstrip uG, Diastix, or glucose enzymatic test strip). ? Monitor renal, hepatic, and hematologic tests if patient receives prolonged therapy.

? 200-mg and 400-mg

chewable

? Amoxicillin may cause less diarrhea than ampicillin. Pregnant patients ? There are no adequate controlled studies in pregnant women, but drug has been used effectively without evidence of adverse effects. Breast-feeding patients ? Drug appears in breast milk; safe use in breast-feeding women hasn’t been established.

Recommend an alternative to breast-feeding during therapy. Pediatric patients ? Pediatric drops may be placed on child’s tongue or added to formula, milk, fruit juice, or soft drink.

Geriatric patients ? Because of diminished renal tubular secretion, half-life may be prolonged in geriatric patients.

Patient education ? Tell patient to chew chewable tablets thoroughly or crush before swallowing and wash down with liquid to ensure adequate absorption of drug; capsule may be emptied and contents swallowed with water.

? Instruct patient to complete full course of medication.

Reactions may be common , uncommon, life-threatening , or COMMON AND LIFE THREATENING .

Intravenous Dose: 30mg/kg/dose (N.B the dose is based on TOTAL drug not the amoxicillin component ) Oral Dose: (N.B the dose is based buy amoxicillin cvs on TOTAL drug not the amoxicillin component ) Indications. Amoxicillin+clavulanic acid should be reserved for treatment of infections where amoxicillin alone is ineffective due to inactivation by beta lactamase enzymes.

It may be used to rationalise antibiotics when infants are receiving amoxicillin and require additional cover against staphylococci that would normally be provided by adding flucloxacillin.

Previous history of jaundice / hepatic

dysfunction

mild renal impairment : no change to dosing schedule; moderate renal impairment : increase the dosing interval. Maintain adequate fluid intake, especially with IV doses, to reduce the possibility of amoxicillin crystalluria.

Cholestatic jaundice – although rarely reported in children. Oral suspension - contains aspartame (source of phenylketonuria) , therefore use with caution in patients with phenylketonuria. The clavulanic acid component protects the amoxicillin from degradation by beta-lactamases, thus extending the spectrum of the amoxicillin. Oral absorption is enhanced by the presence of food. Diarrhoea and vomiting, review therapy if this occurs. Hepatic events - although rarely reported in children. Consult with ID service for use greater than 14 days.

CNS toxicity with high doses or severe renal impairment. Monitor : renal & hepatic function and FBC if on prolonged therapy. Antibiotic prescribing guidelines establish standards of care, focus quality improvement efforts, and improve patient outcomes. The table below summarizes the most recent principles of appropriate antibiotic prescribing for children obtaining care in an outpatient setting for the following six diagnoses: acute rhinosinusitis, acute otitis media, bronchiolitis, pharyngitis, common cold, and urinary tract infection.

A bacterial diagnosis may be established based on the presence of one of the following criteria: Persistent symptoms without improvement: nasal discharge or daytime cough >10 days.

Worsening symptoms: worsening or new onset fever, daytime cough, or nasal discharge after initial improvement of a viral URI.

Severe symptoms: fever ?39°C, purulent nasal discharge for at least 3 consecutive days.

Imaging tests are no longer recommended for uncomplicated cases. Amoxicillin, a member of the penicillin family of antibiotics, is used to treat bacterial infections , including infections of the middle ear . The combination of amoxicillin/clavulanate (Augmentin) is an extended-spectrum antibiotic used to treat bacterial infections resistant to amoxicillin alone. Common brand names: Summary of Interactions with Vitamins, Herbs, & Foods. Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2 , vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less.

People taking tetracycline 1000 mg of amoxicillin for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. Taking large amounts of niacinamide, a form of vitamin B3 , can suppress inflammation in the body.

According to numerous preliminary reports, niacinamide, given in combination with tetracycline or minocycline , may be effective against bullous pemphigoid, a benign, autoimmune blistering disease of the skin.

Preliminary evidence also suggests a similar beneficial interaction may exist between tetracycline and niacinamide in the treatment of dermatitis herpetiformis . Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2 , vitamin B6 , vitamin B12 , vitamin C , and vitamin K .

This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation.

Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. Taking large amounts of niacinamide, a form of vitamin B3 , can suppress inflammation in the body. According to numerous preliminary reports, niacinamide, given in combination with tetracycline or minocycline , may be effective against bullous pemphigoid, a benign, autoimmune blistering disease of the skin. Preliminary evidence also suggests a similar beneficial interaction may exist between tetracycline and niacinamide in the treatment of dermatitis herpetiformis . Neomycin can decrease absorption or increase elimination of many nutrients, including calcium , carbohydrates, beta-carotene , fats, folic acid , iron , magnesium , potassium , sodium, and vitamin A , vitamin B12 , vitamin D , and vitamin K .

Surgery preparation with oral neomycin is unlikely to lead to deficiencies. It makes sense for people taking neomycin for more than a few days to also take a multivitamin-mineral supplement.

Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2 , vitamin B6 , vitamin B12 , vitamin C , and vitamin K .

This is generally not a problem when taking tetracycline for two weeks or less.

People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. Several cases of excessive bleeding have been reported in people who take antibiotics.

This side effect may be the result of reduced vitamin K activity and/or reduced vitamin K production by bacteria in the colon. One study showed that people who had taken broad-spectrum antibiotics had lower liver concentrations of vitamin K2 (menaquinone), though vitamin K1 (phylloquinone) levels remained normal.

Several antibiotics appear to exert a strong effect on vitamin K activity, while others may not have any effect.

Therefore, one should refer to a specific antibiotic for information on whether it interacts with vitamin K. Doctors of natural medicine sometimes recommend vitamin K supplementation to people taking

antibiotics

Additional research is needed to determine whether the amount of vitamin K1 found in some multivitamins is

sufficient

Moreover, most multivitamins do not contain vitamin K.

A common side effect of antibiotics is diarrhea , which may be caused by the elimination of beneficial bacteria normally found in the colon.

A nonpathogenic yeast known as Saccharomyces boulardii has been shown in two double-blind studies to decrease frequency of diarrhea in people taking amoxicillin as well as other penicillin-type drugs compared to placebo.