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Analogue of ampicillin, is a semisynthetic antibiotic with essentially the all patients who present agar (Biokar®) were prepared and sterilized according to the manufacturers’ instructions. Another drug and may not reflect the rates.

Amoxicillin many studies of CAP 50—100 mg/kg/day PO in 3 to 4 divided doses for 14 days. Conditions they’re may also be used 500 mg PO q8hr for 10-14 days. Each) ranges from $4.00 than nasal symptoms every.

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Following administration of ampicillin to pregnant women, a transient decrease in plasma concentration of total conjugated estriol, estriol-glucuronide, conjugated estrone, and estradiol has been noted.

Carcinogenesis, Mutagenesis, Impairment of Fertility. Long-term studies in animals have not been performed to evaluate carcinogenic potential. Studies to detect mutagenic potential of amoxicillin alone have not been conducted; however, the following information is available from tests on a 4:1 mixture of amoxicillin and potassium clavulanate (AUGMENTIN). AUGMENTIN was non-mutagenic in the Ames bacterial mutation assay, and the yeast gene conversion assay. AUGMENTIN was weakly positive in the mouse lymphoma assay, but the trend toward increased mutation frequencies in this assay occurred at doses that were also associated with decreased cell survival. AUGMENTIN was negative in the mouse micronucleus test, and in the dominant lethal assay in mice.

Potassium clavulanate alone was tested in the Ames bacterial mutation assay and in the mouse micronucleus test, and was negative in each of these assays. In a multi-generation reproduction study in rats, no impairment of fertility or other adverse reproductive effects were seen at doses up to 500 mg/kg (approximately 3 times the human dose in mg/m 2 ).

Reproduction studies have been performed in mice and rats at doses up to 10 times the human dose and have revealed no evidence of impaired fertility or harm to the fetus due to amoxicillin.

There are, however, no adequate and well-controlled studies in pregnant women.

Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. In case of overdosage, discontinue medication, treat symptomatically, and institute supportive measures as

required

. If the overdosage is very recent and there is no contraindication, an attempt at emesis or other means of removal of drug from the stomach may be performed.

A prospective study of 51 pediatric patients at a poison-control center suggested that overdosages of less than 250 mg/kg of amoxicillin are not associated with significant clinical symptoms and do not require gastric emptying.

Interstitial nephritis resulting in oliguric renal failure has been reported in a small number of patients after overdosage with amoxicillin.

Crystalluria, in some cases leading to renal failure, has also been reported after amoxicillin overdosage in adult and pediatric patients. In case of overdosage, adequate fluid intake and diuresis should be maintained to reduce the risk of amoxicillin crystalluria. Renal impairment appears to be reversible with cessation of drug administration.

High blood levels

may

occur more readily in patients with impaired renal function because of decreased renal clearance of amoxicillin.

Amoxicillin may be removed from circulation by hemodialysis.

A history of allergic reaction to any of the penicillins is a contraindication.

National Committee for Clinical Laboratory Standards.

Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically ? Fourth Edition; Approved Standard NCCLS Document M7-A4, Vol.

National Committee for Clinical Laboratory Standards.

Performance Standards for Antimicrobial Disk Susceptibility Tests ? Sixth Edition; Approved Standard NCCLS Document M2-A6, Vol.

Swanson-Biearman B, Dean BS, Lopez G, Krenzelok EP.

The effects of penicillin and cephalosporin ingestions in children less than six years of age.

AMOXIL and AUGMENTIN are registered trademarks of GlaxoSmithKline. CLINISTIX is a registered trademark of Bayer Corporation. CLOtest is a registered trademark of Kimberly-Clark Corporation. 1 General 2 Adult Dosing 2.1 General 2.2 Strep Pharyngitis 2.3 Otitis Media 2.4 Sinusitis 2.5 Dental Abscess 2.6 Chlamydial Cervicitis/Urethritis 2.7 Lyme Disease 2.8 Salmonella 2.9 Typhoid Fever 3 Pediatric Dosing 3.1 General 3.2 Otitis Media 3.3 Community Acquired Pneumonia 3.4 Strep Pharyngitis 3.5 Sinusitis 3.6 H. pylori 3.7 Early Lyme Disease 3.8 Salmonella (>3mo) 3.9 Typhoid Fever (>3mo) 4 Special Populations 5 Contraindications 6 Adverse Reactions 6.1 Serious 6.2 Common 7 Pharmacology 8 Antibiotic Sensitivities [1] 8.1 Key 9 See Also 10 References. Type: Amino-Penicillin Dosage Forms: oral solution, capsule, tablet, chewable tablet, extended release tablet Dosage Strengths: oral

solution

: 125, 200, 250, 400mg/5 mL; capsule: 250, 500mg; tablet: 500, 875mg; chewable tablet: 125, 250mg; extended release tablet: 775mg Routes of Administration: PO Common Trade Names: Amoxil; Moxatag, Trimox. Acute Immunocompetent 500mg PO q8h x 3-7 days Immunocompromised 1000mg PO q8h x 3-14 days Chronic carrier 1000mg PO q8h x 3 months.

50-100mg/kg/day PO divided q6-8h x 14 days First Dose: 12.5mg-33.3mg/kg PO x 1. 3mo: 25-45mg/kg/day PO divided q12h First Dose: 12.5-22.5mg/kg PO x 1 Max: 875mg/dose. 90mg/kg/day PO divided q12h x 5-10 days First Dose: 45mg/kg PO x 1 Max 3 months - 4 years: 500mg/dose >5 years: 4000mg/day.

90mg/kg/day PO divided q8-12h x 10 days Max: 1000mg/dose.

50mg/kg/day PO divided BID x 7-14 days Max: 2000mg/day.

50mg/kg/day PO divided q8h x 14-21 days First Dose: 16.6mg/kg PO x1 Max: 500mg/dose.

3mo)"> Salmonella (>3mo) 50-100mg/kg/day PO divided q8-12h Acute: x 3-7 days Acute Immunocompromised: 10-14 days Chronic: 3 months.

3mo)"> Typhoid Fever (>3mo) Not 1st line treatment.

BIOMOX ® (amoxicillin) Tablets and BIOMOX ® (amoxicillin) Oral Suspension. BIOMOX ® (amoxicillin) Tablets and BIOMOX ® (amoxicillin) Oral Suspension are a semi-synthetic, broad-spectrum amoxicillin, indicated for the treatment of bacterial dermatitis and soft tissue infections, including abscesses, wounds and lacerations in dogs when caused by susceptible strains of organisms: BACTERIAL DERMATITIS due to Staphylococcus aureus, Streptococcus spp., Staphylococcus spp., and E. coli SOFT TISSUE INFECTIONS (abscesses, wounds, lacerations) due to Staphylococcus aureus, Streptococcus spp., E.

As is true with all antibiotic therapy, appropriate in vitro cultures and sensitivities should be conducted prior to treatment.

Provides excellent bactericidal activity against a wide variety of common gram-negative and gram-positive pathogens Available in 2 convenient formulation options: Tablets are available in 50 mg, 100 mg and 200 mg concentrations in bottles of 500 tablets Suspension is available in 15 mL and 30 mL sizes with 50 mg/mL potency when reconstituted.



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