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Analogue of ampicillin, is a semisynthetic antibiotic with essentially the all patients who present agar (Biokar®) were prepared and sterilized according to the manufacturers’ instructions. Another drug and may not reflect the rates.

Hip replacement participated in this controlled effects and study discontinuation in the randomized clinical trials safety evaluations were carried out throughout the whole study period (from visit 1 to visit. Antibiotic use in 76 countries over.

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Antimicrob Agents Chemother 1978;13:559-65.  [PubMed] 262.

Clin Neuropharmacol 1987;10:483-510.  [PubMed] 263. Woods CR, Smith AL, Wasilauskas BL, Campos J, Givner LB. Invasive disease caused by Neisseria meningitidis  relatively resistant to penicillin in North Carolina.

Antibiotic cost savings from formulary resitrictions and physician monitoring in a medical-school affiliated hospital. Yamamoto M, Jimbo M, Ide M, Tanaka N, Umebara Y, Hagiwara S.

Penetration of intravenous antibiotics into brain abscesses. Diffusion of β-lactam antibiotics through the porin channels of Escherichia coli K-12. Antimicrob Agents Chemother 1985;27:84-92.  [PubMed] 268. Studies on the pathogenesis of the Jarisch-Herxheimer reaction.

Yu VL, Chiou CC, Feldman C, Ortqvist A, Rello J, Morris AJ, Baddour LM, Luna CM, Snydman DR, Ip M, Ko WC, Chedid MB, Andremont A, Klugman KP; International Pneumococcal Study Group. An international prospective study of pneumococcal bacteremia: correlation with in vitro  resistance antibiotics administered and clinical outcome. Cefuroxime by continuous infusion: a new standard of care?

Rev Infect Dis 1990;Suppl 6:590-609.  [PubMed] 272.

Effect of dose and schedule on cefoperazone pharmacodynamics in an in vitro  model of infection in a neutropenic host. Am J Med 1988;85(Suppl 1A):56-8.  [PubMed] Tables.

Class and compounds  Trade names 1      Availability Natural penicillins  penicillin G potassium Pfizerpen

Parenteral

: 5, 20 mu vials phenoxymethyl penicillin various generics Tablets: 250, 500mg Solution: 125mg/5 mL, 250mg/5 mL penicillin G procaine Wycillin  Parenteral: 600,000 u/mL penicillin G benzathine Bicillin L-A, Permapen Parenteral: 300,000u/mL, 600,000u/mL penicillin G procaine/ penicillin G benzathine combination Bicillin C-R Parenteral: 150,000u/150,000 u/mL, 150,000/450,000 u/mL, amoxil 1 gr 300,000/30,000 u/mL Penicillinase-Resistant Penicillins  methicillin Staphcillin no longer available nafcillin various generics Parenteral: 20 mg/mL vials oxacillin Bactocill Capsules:

250

, 500mg Solution: 250mg/5mL Parenteral: 500mg, 1, 2, 4 g vials cloxacillin various generics Capsules: 250, 500mg Solution: 125mg/5 mL dicloxacillin Dynapen Capsules: 250, 500mg Suspension: 62.5 mg/5 mL Aminopenicillins   ampicillin Principen Capsules: 250, 500 mg Suspension: 125 mg/5 mL, 250 mg/5 mL Parenteral: 125, 250, 500 mg, 1, 2 g vials amoxicillin Amoxil,  Trimox Capsules: 250, 500 mg Chewable tablets: 125, 250, 400 mg Film-coated tablets: 500, 875 mg Suspension: 50mg/mL, 125 mg/5 mL, 200 mg/5 mL, 250 mg/5 mL, 400 mg/5 mL bacampicillin Spectrobid no longer available Carboxypenicillins  carbenicillin Geocillin Tablets: 382 mg ticarcillin Ticar Parenteral: 1, 3, 6 g vials Ureidopenicillins and piperazine penicillin  azlocillin Azlin no longer available in U.S.

market mezlocillin    Mezlin no longer available in U.S.

market piperacillin Pipracil  Parenteral: 2, 3, 4g vials. 1 = not all formulations are available with every brandÂ.

Table 2.  Minimal Inhibitory Concentrations (MIC50) of Specific OrganismsÂ.

 MIC-50 (µg/mL) Organism Penicillin G Penicillin V Oxacillin Ampicillin/Amoxicillin Ticarcillin Mezlocillin Piperacillin Gram-Positive aerobes       Enterococcus sp. 2.0 4.0 >32 0.5 64 2 Staphylococcus aureus         (Non Penicillinase producing) 0.03 0.03 0.4 0.06 1.0 0.06   (Penicillinase-producing) >32 >32 1.6 >32 32 32 Staphlyococcus epidermidis 0.02 0.02 0.2 0.05 1.0 1.0 Streptococcus pneumoniae 0.01 0.01 0.1 0.02 0.4 0.02 Viridans streptococci 0.01 0.01 0.2 0.05 0.5 0.25 Streptococcus pyogenes 0.015 0.015 0.04 0.03 0.25 0.125

Listeria

monocytogenes 0.25 0.25 >4 0.25 4 0.5 Gram-negative aerobes       Neisseria gonorrhoeae a 0.25  1.0 0.06 0.03 0.015 Neisseria meningitidis 0.03  0.06 0.06 0.03 0.03 Escherichia coli 64 128 8 2 4 2 Proteus mirabilis 32 128 4 0.5 2 1 Indole + P.

mirabilis >500  >500 >128 64 4 1 Hemophilus influenzaea 0.4 6.3 25 0.25 0.012 0.03 Salmonella sp. 16 64  4   Serratia marcescens >128 >128 >128 >500 16 88 Klebsiella sp. >128 >128 >128 16 8 16 Pseudomonas aeruginosa >128 >128 >128 >500 16 8 Anaerobes       Peptostreptococcus 0.1  >32 0.5 0.5 0.5 Fusobacterium nucleatum 64 64 64 16 16 32.

Minimal Inhibitory Concentrations (MIC-90) of Specific OrganismsÂ. Table 4. In Vitro  Post-Antibiotic Effect of Selected Penicillins.

faecalis penicillin G 2-3.5 hrs 2.5-3.5 hrs 2.5-3.5 hrs ampicillin 2-2.5 hrs 2-6 hrs 0.5-2.5 hrs nafcillin 1.5-2 hrs ND ND piperacillin £0.5 hr ND £0.5 hr. Prevalence of Resistance of Organisms to Penicillins.

Organism Prevalence Gram-positive  Streptococcus pneumoniae a,b Intermediate pcn resistance 11-28% Highly PCN resistant 11-33% Staphylococcus aureus PCN resistant >95%, Methicillin resistant (nosocomial) 23-38% Gram-negative  Haemophilus influenzae ampicillin 1-64% Moraxella catarrhalis up to 85% Escherichia coli ampicillin 30-50% Neisseria gonorrhoeae 1.2-38% Neisseria meningitidis up to 20% Extended-spectrum beta-lactamase producers  Klebsiella pneumoniae up to 24% Pseudomonas aeruginosa piperacillin 5-30% a intermediate resistant strains have MICs of 0.12-1.0 µg/mL.

highly resistant strains have MICs of ³2.0 µg/mL.

Table 6. Pharmacokinetic Properties of  Penicillins.

1 % Bioavailability Half-Life (hours) %PPB 2 Natural penicillins      benzylpenicillin 2g 20 µg/mL na 0.5 50-60 penicillin G oral 3 400,000 u 0.3 µg/mL 15-30 0.5  penicillin VK 250 mg 3 µg/mL 60 0.5 75-85 procaine pen G IM 300,000 u 0.9 µg/mL    benzathine pen G IM 1.2 mu 0.09 µg/mL     Penicillinase-resistant penicillins      nafcillin IV 1g 20 µg/mL na 0.5-1.0 90 oxacillin IV 500mg 52-63µg/mL na 0.5-0.7 94 oxacillin oral 500mg 5-7 µg/mL 30-35% 0.5-0.7  cloxacillin oral 500mg 7.5-14µg/mL 50 0.5 95 dicloxacillin oral 500mg 10-17µg/mL 37 0.8 98 Aminopenicillins      ampicillin IV 1g 40 µg/mL na 1-1.3 20 ampicillin oral 1g  3 µg/mL 30-50 1-1.3  amoxicillin oral 1g 7.5 µg/mL 80 1-1.3 20 Extended-spectrum penicillins      carbenicillin IV 3g 223 µg/mL na 1.1 50 carbenicillin oral 1g 9 µg/mL 30   ticarcillin 3.5g 210 µg/mL na 1.2 45 mezlocillin 3g 263 µg/mL na 0.8 16-42 piperacillin 4g 240 µg/mL na 1.0 16.

                                          Â. 1 data complied from product package information and Donowitz 1988. Table 7. Guidelines for Adult and Pediatric Dosing of Penicillins. Drug Normal adult dose a,b

Normal

pediatric dose c  Dosage adjustment in renal impairment d,e Natural penicillins    benzylpenicillin (penicillin G) enterococcal endocarditis: 4-6 mub IV q4h ? 1week and > 2kg: 20,000-50,000 u/kg IV q8h CrCL 10-50 mL/min: Increase dosing interval to q6-8h ? 1 week and ? 2kg: 20,000-50,000 u/kg IV q12h > 1 week and ? 2kg: 25,000-65,000 u/kg IV q8h Streptococcal meningitis: 2-3 mu IV q4h > 1 week and > 2kg: 25,000-65,000 u/kg IV q6h Streptococcal infection: 2mu IV q4-6h > 1month and 12 years: usual adult dose CrCL 12 years: usual adult dose  neurosyphilis: 3-4 mu IV q4h   penicillin VK Streptococcal pharyngitis: 500 mg po bid-tid for 10 days > 1 month: 15-62.5 mg/kg/day po in 3-6 divided doses Little data available. Adjust dose if CrCL 1 month and 1 month: 50-100 mg/kg/day po in

3-4

divided doses CrCL 1 month: IV data limited, 100-200mg/kg/day in 4-6 divided doses oxacillin 500mg-1g po q4-6h  > 1 month and 1 month and 1 month and 40 kg: usual adult dose CrCL 1 month and 20 kg: usual adult dose CrCL 1 month and a intramuscular. c These dosages are ranges of acceptable doses. The lower range of usual dose is generally used for mild infection, upper range for severe infection (e.g.

meningitis, endocarditis). Higher dosages than recommended may be used in certain circumstances. Clinical judgment should be used when dosing and prescribing information for the specific drugs should be consulted for more information. d clinical judgment should be utilized when making decisions regarding dosage adjustment in renally impaired patients, taking into account severity of renal impairment, site of infection, expected length of therapy, organism isolated, etc. e data complied using McEvoy 2003 AHFS Drug Information and product package inserts. Table 8. Approximate Cost of Typical Therapeutic Regimens of Selected Penicillins 1.

Drug Dosing regimen Cost 1 Oral agents   ampicillin 500mg po q6h x 10d $5.00 penicillin VK 500mg po q8h x 10d $4.00 amoxicillin 500mg po q8h x 10d $5.00 Long-acting agents   procaine penicillin G 1.2 mu IM x1 $5.00 benzathine penicillin G 2.4mu IM x1 $15.00 Intravenous agents   ampicillin 2g IV q4h x 10d $57.00 penicillin G potassium 2 mu IV q4h x 10d $21.00 penicillin G sodium 2 mu IV q4h x 10d $158.00 oxacillin 1g IV q6h x 10d $109.00 ticarcillin 3g IV q4h x 10d $375.00 piperacillin 4g IV q6h x 10d $390.00.

1Â = drug acquisition costs for Albany Medical Center Hospital, Albany, New York.

Antibiotics are medications used to fight infections caused by bacteria. They treat infections by killing or decreasing the growth of bacteria.

Before antibiotics, 30 percent of all deaths were caused by bacterial infections. Thanks to antibiotics, previously fatal infections are curable.

Today, antibiotics are still powerful, life-saving medications for people with certain serious infections.

They can also prevent less-serious infections from becoming serious.

Certain types of antibiotics work best for specific types of bacterial infections.

Antibiotics come in many forms, including: tablets capsules liquids creams ointments. Most antibiotics are only available with a prescription from your doctor. Some antibiotic creams and ointments are available over the counter.

Antibiotics fight bacterial infections either by killing bacteria or slowing and suspending its growth. They do this by: attacking the wall or coating surrounding bacteria interfering with bacteria reproduction blocking protein production in bacteria. Antibiotics begin to work right after you start taking them.

However, you might not feel better for two to three days.

How quickly you get better after antibiotic treatment varies.

It also depends on the type of infection you’re treating. In some cases, shorter treatments work just as well.

Your doctor will decide the best length of treatment and correct antibiotic type for you. Even though you might feel better after a few days of treatment, it’s best to finish the

entire

antibiotic regimen in order to fully resolve your infection. Don’t stop your antibiotic early without first talking with your healthcare provider.

The first beta-lactam antibiotic, penicillin, was discovered by accident.

It was growing from a blob of mold on a petri dish. Scientists found that a certain type of fungus naturally produced penicillin.

Eventually, penicillin was produced in large quantities in a laboratory through fermentation using the fungus.

Some other early antibiotics were produced by bacteria found in ground soil. Today, all antibiotic medications are produced in a lab.

Some are made through a series of chemical reactions that produce the substance used in the medication. Other antibiotics are at least partially made through a natural but controlled process. This process is often enhanced with certain chemical reactions that can alter the original substance to create a different medication. Antibiotics are powerful medications that work very

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04.12.2018 - crazy_girl
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08.12.2018 - Agayev
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09.12.2018 - Enigma_Flawers
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12.12.2018 - Gozel
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15.12.2018 - SYRAX
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17.12.2018 - 666_SaTaNa_666
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19.12.2018 - 1818
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22.12.2018 - TIMON
Similar to penicillin, it covers most 20% of people with the tick-borne illness, the.
25.12.2018 - 0110
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29.12.2018 - DolmakimiOglan
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30.12.2018 - SEKS_POTOLOQ
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31.12.2018 - sebuhi
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02.01.2019 - EFIR_QAQASH
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05.01.2019 - svetlana
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06.01.2019 - emo_girl
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07.01.2019 - Patriot
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09.01.2019 - raxul
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13.01.2019 - LOST
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15.01.2019 - BubsY
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18.01.2019 - mia
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21.01.2019 - SuperDetka_sexy
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22.01.2019 - TT
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