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First generation cephalosporins such as cefazolin , nafcillin , or clindamycin are also appropriate choices. M eningitis and Brain Abscess: Meningitis and brain abscesses are rare complications of group A streptococcus that can occur either from direct extension of acute pharyngitis or sinusitis or from bacteremic spread. Penicillin is still the drug of choice for treatment of known group A streptococcal meningitis or brain abscess (12). Antimicrobial therapy should be given parenterally for 10 to 14 days (12). Patients allergic to penicillin can be treated with a third generation cephalosporin such as ceftriaxone or cefotaxime (12). A rthritis: Post-streptococcal reactive arthritis (PSRA) is a recognized complication of group A streptococcal infections. Antibiotic therapy aimed at the underlying focus of infection is generally all that is required. However, anti-inflammatory drugs may aid patient comfort. Of concern, is the risk that a subset of patients with PSRA may develop rheumatic heart disease. This has led some to suggest that patients with PSRA, like patients who have had ARF, may require antimicrobial prophylaxis to prevent the occurrence of rheumatic heart disease (20). It has been recommended that these patients receive prophylaxis for 1 year, and then if no evidence of rheumatic heart disease develops, prophylaxis could be discontinued (20). Septic arthritis secondary to group A streptococcal infection can result from direct inoculation or bacteremic spread. Therapy consists of parenteral antibiotics given for 10 to 14 days. Choices include a third generation cephalosporin, such as ceftriaxone and cefotaxime , or beta lactams such as nafcillin or penicillin . In addition, surgical drainage of purulent material from the joint space is required. E ndocarditis: Endocarditis due to group A streptococcus was relatively common during the preantibiotic era. Therapy aimed at the most common organisms in endocarditis also provides coverage for group A streptococcus and should be continued for 4 to 6 weeks. Patients with known GAS endocarditis have been treated successfully with 6 weeks of parenterally administered penicillin (53). O steomyelitis : Like septic arthritis, osteomyelitis secondary to group A streptococcal infection is known, but rare. Therapy consists of appropriate antimicrobials given parenterally to control the infection. If group A streptococcus has been identified as the etiologic agent, penicillin can be used. Patients allergic to penicillin can be treated with clindamycin , vancomycin, or cefazolin . L iver Abscess: Liver abscesses secondary to group A streptococcal infection generally result from hematogenous spread. Therapy consists of long term parenterally administered penicillin and surgical drainage. Initially, until an etiologic agent has been determined, a combination of a penicillinase-resistant penicillin, such as nafcillin , and an aminoglycoside should be used. Treatment should consist of 2 to 4 weeks of parenterally administered antibiotics followed by oral antibiotics to complete a 4 week course. Patients allergic to penicillin can be treated with clindamycin , vancomycin, or an appropriate first generation cephalosporin. A cute Rheumatic Fever: Treatment of patients with acute rheumatic fever is generally directed toward decreasing acute inflammation, decreasing fever and toxicity, controlling cardiac failure, preventing episodes of recurrent ARF after significant streptococcal upper respiratory tract infections, and preventing rheumatic heart disease. The mainstays of treatment are salicylates and corticosteroids. Neither of these amoxicillin and potassium clavulanate tablets price agents prevents or modifies the development of rheumatic heart disease. Patients clinically diagnosed with ARF who have not received antimicrobial therapy for a recent episode of GAS pharyngitis should receive a 10 day course of penicillin . Primary prevention of ARF depends on accurate diagnosis of an antecedent streptococcal infection as well as adequate therapy. Penicillin given orally for 10 days or intramuscularly one time will prevent rheumatic fever. Erythromycin is considered the drug of choice f the treatment of GAS pharyngitis in penicillin-allergic patients, but it has not been shown to prevent ARF (17). Approximately one third of patients who develop ARF have streptococcal infections that are either subclinical or too mild to be brought to medical attention; as a result, they receive no antibiotic therapy for the infection. Recent reports have suggested that up to 75% of patients with ARF either had no history of a preceding streptococcal infection or had an infection that was so mild they did not seek medical attention. In contrast, in the past, preceding streptococcal infections were noted to be severe (55). Of even more concern are reports of patients who develop ARF despite receiving adequate therapy for GAS pharyngitis (21). Possible explanations for this include poor patient compliance with antibiotic therapy, a shorter latency period, documented streptococcal infections were not the cause of the resultant episodes of ARF, or currently recommended therapies for GAS pharyngitis have become inadequate for prevention of ARF (15). Only one series of studies has ever documented prevention of ARF following antimicrobial therapy for GAS pharyngitis. These studies were conducted during the 1940s on army recruits at Fort Warren, Wyoming. Penicillin G suspended in oil, administered parenterally in a placebo-controlled study, decreased the incidence of ARF (90). Following these studies, researchers compared orally administered penicillin with parenterally administered penicillin and found equivalent bacteriologic effects.
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