Amoxicillin for swollen lymph nodes

Lyme Disease (Off-label) Chronic migrating rash and other symptoms of early dissemination.

500 mg orally every 8 hours (depending on size of patient) for 3-4 weeks. 50 mg/kg/day every 8 hours in divided doses; maximum 500 mg/dose.

Chlamydial Infection in Pregnant Women (Off-label) First trimester: 500 mg orally every 8 hours for 7 days. First trimester: Test to document chlamydial eradication and retest for infection 3 months after treatment.

Second or third trimester: Test to document chlamydial eradication.

For use when susceptibility test results show susceptibility to amoxicillin, indicating no beta-lactamase production. Renal impairment: Patients with impaired renal function do not generally require dose reduction unless impairment is severe; do not administer extended-release product in patients with creatinine clearance under 30 mL/min.

GFR under 30 mL/min: Should not receive 875 mg (immediate release) or 775 mg (extended release) GFR 10-30 mL/min: 250-500 mg every 12 hours, depending on severity of infection.

GFR under 10 mL/min: 250-500 mg every 24 hours depending on severity of infection. Hemodialysis patients: 250-500 mg every 24 hours, depending on severity of infection; patients should receive additional dose during and at completion of dialysis; do not administer extended-release product or 875 mg immediate release. Pediatric Dosages Considerations: Ear, Nose, and Throat Infections.

Under 3 months: 30 mg/kg/day orally divided every 12 hours for 48-72 hours; for less than 10 days for S pyogenes infections.

Older than 3 months and under 40 kg: 25 mg/kg/day orally divided every 12 hours or 20 mg/kg/day orally divided every 8 hours.

Over 40 kg: 500 mg orally every 12 hours or 250 mg orally every 8 hours for 10-14 days. Under 3 months: 30 mg/kg/day orally divided every 12 hours for 48-72 hours; for less than 10 days for S pyogenes infections.

Older than 3 months and less than 40 kg: 45 mg/kg/day orally divided every 12 hours or 40 mg/kg/day orally divided every 8 hours. Over 40 kg: 875 mg orally every12 hours or 500 mg orally every 8 hours for 10-14 days.

50 mg/kg orally every day for 10 days, not to exceed 1 g/day, orally 25 mg/kg orally twice daily for 10 days, not to exceed 500 mg/dose.

Older than 12 years: 775 mg (Moxatag) orally once per day for 10 days, taken within 1 hour after meal (swallow tablet whole; do not crush or chew) Acute Otitis Media. Older than 3 months and under 40kg: 80-90 mg/kg/day orally divided every 8-12 hours. Over 40 kg: 500 mg orally every 12 hours or 250 mg orally every 8 hours for 10-14 days.

Under 3 months: greater than or equal to 30 mg/kg/day orally divided every 12 hours for 48-72 hours; for less than 10 days for S pyogenes infections. Older than 3 months and under 40 kg: 45 mg/kg/day orally divided every 12hr or 40 mg/kg/day orally divided every 8 hours. Over 40kg: 875 mg orally every 12 hours or 500 mg orally every 8 hours for 10-14 days.

pneumoniae is the primary pathogen that causes pneumonia in patients 5-15 years old, a macrolide antibiotic may be a first choice treatment. Under 3 months: Safety and efficacy not established. Older than 3 months: Empiric treatment: 90 mg/kg/day orally divided every 12 hours for 10 days; not to exceed 4,000 mg/day. Group A Streptococcus: 50-75 mg/kg/day orally divided every 12 hours for 10 days; not to exceed 4,000 mg/day.

influenza: 75-100 mg/kg/day orally divided every 8 hours for 10 days; not to exceed 4,000 mg/day.

pneumoniae (mild infection or step-down therapy or when MICs to penicillin equal to or greater than 2.0 mcg/mL): 90 mg/kg/day orally divided every 12 hours or 45 mg/kg/day divided every 8 hours for 10 days; not to exceed 4,000 mg/day.

Anthrax (Off-label) Post exposure inhalational prophylaxis. Under 40 kg: 15 mg/kg orally every 8 hours (minimum recommended dose; should not be greater than 45 mg/kg/day or given less than every 8 hours. 80 mg/kg/day orally divided every 8 hours for 4 weeks (with simultaneous vaccine) or for 60 days (without vaccine) Infective Endocarditis (Off-label) 50 mg/kg orally 30-60 min before procedure. AHA guidelines recommend prophylaxis only in high-risk patients undergoing invasive procedures with history of cardiac conditions that predispose them to infection. Lyme Disease (Off-label) Chronic migrating rash and other symptoms of early dissemination.

Under 3 months: Safety and efficacy not established.

Over 3 months and 40 kg: 25-50 mg/kg/day divided every 8 hours; not to exceed 500 mg. Mixing oral suspension: Tap bottle until all powder flows freely; add approximately one third of the total amount of water for reconstitution and shake vigorously to wet powder; add remainder of water and shake vigorously again. After reconstitution, place required amount of suspension directly on child's tongue for swallowing; if taste is unacceptable, required amount of suspension can be added to formula, milk, fruit juice, water, ginger ale, or other cold drinks; preparation must be taken immediately.

Shake suspension well before using; any unused portion must be discarded after 14 days. What Are Side Effects Associated with Using Amoxicillin?

Common side effects of amoxicillin include: acuteallergic reaction anemia elevated liverenzymes persistent superficial infections of the skin diarrhea headache nausea vomiting rash antibiotic associated inflammation of the colon serum sickness-like reactions.

Post marketing side effects of Amoxicillin reported include: persistent superficial infections of the skin gastrointestinal black hairy tongue hemorrhagic/pseudomembranous colitis (may occur during or after treatment) Hypersensitivity reactions liver dysfunction cholestatic jaundice hepaticcholestasis acute cytolytic hepatitis Renal (crystalluria) Anemia hemolytic anemia Low platelet count (thrombocytopenia) thrombocytopenic purpura eosinophilia Low white blood cell count (leukopenia) agranulocytosis Central nervous system reactions reversible hyperactivity agitation anxiety insomnia confusion convulsions behavioral changes dizziness Tooth discoloration (brown, yellow or gray staining) This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects. If your doctor has directed you to use this medication for diabetes, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Severe Interactions of Amoxicillin include: Amoxicillin has moderate interactions with at least 27 different drugs.

Mild Interactions of Amoxicillin include: amiloride azithromycin aztreonam chloramphenicol clarithromycin erythromycin base erythromycin ethylsuccinate erythromycin lactobionate erythromycin stearate pyridoxine (antidote) This document does not contain all possible interactions.

Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Check with your physician if you have health questions or concerns. Documented hypersensitivity to penicillins, cephalosporins, and imipenem.

Do not take Amoxil, Moxatag, or Trimox, if you are allergic to amoxicillin or any ingredients contained in this drug.

In case of overdose, get medical help or contact a Poison Control Center immediately.

See "What Are Side Effects Associated with Using Amoxicillin?" Long-Term Effects.

See "What Are Side Effects Associated with Using Amoxicillin?" Cautions.

Severe allergic reaction has been reported rarely but is more likely to occur following parenteral therapy with penicillins.

Clostridium difficile-associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents; severity may range from mild diarrhea to fatal colitis; CDAD may occur over 2 months after discontinuation of therapy; if CDAD is suspected or confirmed, discontinue immediately and begin appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C difficile, and surgical evaluation. Do not administer in patients with infectious mononucleosis or mono because of risk of development of red skin rash.

Do not administer to patients in the absence of a proven or suspected bacterial infection because of

risk

Chewable tablets contain aspartame, which contains phenylalanine.

Use caution in patients with allergy to cephalosporins, carbapenems.

Endocarditis prophylaxis: use for only high-risk patients, as per recent AHA guidelines.

High doses may cause false urine glucose test by some methods.

Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. Amoxicillin is a penicillin antibiotic that is used to treat many different types of infection caused by bacteria, such as tonsillitis, bronchitis, pneumonia, and infections of the ear, nose, throat, skin, or urinary tract. Amoxicillin is also sometimes used together with another antibiotic called clarithromycin (Biaxin) to treat stomach ulcers caused by Helicobacter pylori infection.

This combination is sometimes used with a stomach acid reducer called lansoprazole (Prevacid).

Amoxicillin may also be used for purposes not listed in this medication guide. Bacterial Endocarditis Prophylaxis Helicobacter pylori Infection Lyme Disease -- Arthritis Lyme Disease -- Carditis Lyme Disease -- Erythema Chronicum Migrans Otitis Media Pneumonia Sinusitis Skin or Soft Tissue Infection Tonsillitis/Pharyngitis Urinary

Tract

You should not use this medicine if you are allergic to any penicillin antibiotic, such as ampicillin, dicloxacillin, oxacillin, penicillin, or ticarcillin.

Tell your doctor if you have ever had: kidney disease; mononucleosis (also called "mono"); diarrhea caused by taking antibiotics; or food or drug allergies (especially to a cephalosporin antibiotic such as Omnicef, Cefzil, Ceftin, Keflex, and others).

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Amoxicillin can make birth control pills less effective. Ask your doctor about using a non-hormonal birth control (condom, diaphragm, cervical cap, or contraceptive sponge) to prevent pregnancy. It may not be safe to breastfeed while using this medicine. The following conditions are contraindicated with this drug. Check with your physician if you have any of the following: Conditions: diarrhea from an infection with Clostridium difficile bacteria mononucleosis the kissing disease liver problems blockage of normal bile flow severe renal impairment. Selected from data included with permission and copyrighted by First Databank, Inc.

This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions,

precautions

Formulations of AMOXIL contain amoxicillin, a semisynthetic antibiotic, an analog of ampicillin, with a broad spectrum of bactericidal activity against many Gram-positive and Gram-negative microorganisms. Chemically, it is (2S,5,R,6,R)-6-[(,R)-(-)-2-amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate.

It may be represented structurally as: The amoxicillin molecular formula is C 16 H 19 N 3 O 5 S•3H 2 O, and the molecular weight is 419.45.

Capsules : Each capsule of AMOXIL, with royal blue opaque cap and pink opaque body, contains 250 mg or 500 mg amoxicillin as the trihydrate.

The cap and body of the 250-mg capsule are imprinted with the product name AMOXIL and 250; the cap and body of the 500-mg capsule are imprinted with AMOXIL and 500. 40, gelatin, magnesium stearate, and titanium dioxide. Tablets : Each tablet contains 500 mg or 875 mg amoxicillin as the trihydrate. Each film-coated, capsule-shaped, pink tablet is debossed with AMOXIL centered over 500 or 875, respectively.

Inactive ingredients: Colloidal silicon dioxide, crospovidone, FD&C Red No. 30 aluminum lake, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, sodium starch glycolate, and titanium dioxide.

Powder for Oral Suspension : Each 5 mL of reconstituted suspension contains 125 mg, 200 mg, 250 mg or 400 mg amoxicillin as the trihydrate.

Each 5 mL of the 125-mg reconstituted suspension contains 0.11 mEq (2.51 mg) of sodium. Each 5 mL of the 200-mg

reconstituted

AMOXIL® is indicated in the treatment of infections due to susceptible (ONLY ?-lactamase–negative) isolates of Streptococcus species. (?-and ?-hemolytic isolates only), Streptococcus pneumoniae, Staphylococcus spp., or Haemophilus influenzae . AMOXIL® is indicated in the treatment of infections due to susceptible (ONLY ?-lactamase–negative) isolates of Escherichia coli, Proteus mirabilis , or Enterococcus faecalis . AMOXIL® is

indicated

Triple Therapy for Helicobacter Pylori with Clarithromycin and Lansoprazole.

AMOXIL, in combination with clarithromycin plus lansoprazole as triple therapy, is indicated for the treatment of patients with H.

pylori infection and duodenal ulcer disease (active or 1-year history of a duodenal ulcer) to eradicate H.

pylori has been shown to reduce the risk of duodenal ulcer recurrence.

AMOXIL, in combination with lansoprazole delayed-release capsules as dual therapy, is indicated for the treatment of patients with H.

pylori infection and duodenal ulcer disease (active or 1-year history of a duodenal ulcer) who are either allergic or intolerant to clarithromycin or in whom resistance to clarithromycin is known or suspected.

(See the clarithromycin package insert , Microbiology .) Eradication of H.

pylori has been shown to reduce the risk of duodenal ulcer recurrence. To reduce the development of drug-resistant bacteria and maintain the effectiveness of AMOXIL (amoxicillin) and other antibacterial drugs, AMOXIL should be used only to treat infections that are proven or strongly suspected to be caused by bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy.

In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Dosing For Adult And Pediatric Patients > 3 Months Of Age.

Treatment should be continued for a minimum of 48 to 72 hours beyond the time that the patient becomes asymptomatic or evidence of bacterial eradication has been obtained.

It is recommended that there be at least 10 days' treatment for any infection caused by Streptococcus pyogenes to prevent the occurrence of acute rheumatic fever. In some infections, therapy may be required for several weeks. It may be necessary to continue clinical and/or bacteriological follow-up for several months after cessation of therapy. Table 1: Dosing Recommendations for Adult and Pediatric Patients > 3 Months of Age Infection Severity a Usual Adult Dose Usual Dose for Children > 3 Months b Ear/Nose/Throat Skin/Skin Structure Genitourinary Tract Mild/Moderate 500 mg every 12 hours or 250 mg every 8 hours 25 mg/kg/day in divided doses every 12 hours or 20 mg/kg/day in divided doses every 8 hours Severe 875 mg every 12 hours or 500 mg every 8 hours 45 mg/kg/day in divided doses every 12 hours or 40 mg/kg/day in divided doses every 8 hours Lower Respiratory Tract Mild/Moderate or Severe 875 mg every 12 hours or 500 mg every 8 hours 45 mg/kg/day in divided doses every 12 hours or 40 mg/kg/day in divided doses every 8 hours a Dosing for infections caused by bacteria that are intermediate in their susceptibility to amoxicillin should follow the recommendations for severe infections. b

The