Amoxicillin capsules 250mg

Amoxicillin fully dissociates in aqueous solution at physiological pH.

It is rapidly and well absorbed by the oral route of administration. Following oral administration, amoxicillin is approximately 70% bioavailable. The time to peak plasma concentration (T max ) is approximately one hour.

The pharmacokinetic results for a study, in which an amoxicillin dose of 250 mg three times daily was administered in the fasting state to groups of healthy volunteers are presented below. In the range 250 to 3000 mg the bioavailability is linear in proportion to dose (measured as C max and AUC).

The absorption is not influenced by simultaneous food intake.

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Following intravenous administration, amoxicillin has been found in gall bladder, abdominal tissue, skin, fat, muscle tissues, synovial and peritoneal fluids, bile and pus. Amoxicillin does not adequately distribute into the cerebrospinal fluid.

From animal studies there is no evidence for significant tissue retention of drug-derived material.

Amoxicillin, like most penicillins, can be detected in breast milk (see section 4.6).

Amoxicillin has been shown to cross the placental barrier (see section 4.6).

Amoxicillin is partly excreted in the urine as the inactive penicilloic acid in quantities equivalent to up to 10 to 25% of the initial dose.

The major route of elimination for amoxicillin is via the kidney.

Amoxicillin has a mean elimination half-life of approximately one hour and a mean total clearance of approximately 25 l/hour in healthy subjects. Approximately 60 to 70% of the amoxicillin is excreted unchanged in urine during the first 6 hours after administration of a single 250 mg or 500 mg dose of amoxicillin.

Various studies have found the urinary excretion to be 50-85% for amoxicillin over a 24 hour period. Concomitant use of probenecid delays amoxicillin excretion (see section 4.5). The elimination half-life of amoxicillin is similar for children aged around 3 months to 2 years and older children and adults.

For very young children (including preterm newborns) in the first week of life the interval of administration should not exceed twice daily administration due to immaturity of the renal pathway of elimination.

Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function. Following oral administration of amoxicillin/ to healthy males and female subjects, gender has no significant impact on the pharmacokinetics of amoxicillin. The total serum clearance of amoxicillin decreases proportionately with decreasing renal function (see sections 4.2 and 4.4).

Hepatically impaired patients should be dosed with caution and hepatic function monitored at regular intervals. Non-clinical data reveal no special hazard for humans based on studies of safety pharmacology, repeated dose toxicity, genotoxicity and toxicity to reproduction and development.

Carcinogenicity studies have not been conducted with amoxicillin.

Sounds like 'amox-i-cil-lin' Overview Clinicians Clinicians Dose calculator. Easy-to-read medicine information about amoxicillin – what is it, how to take it safely and possible side effects.

Amoxicillin is an antibiotic used to treat different infections caused by bacteria, such as chest infections, dental infections and infections of the throat, ear and sinus.

It works by killing or stopping the growth of bacteria (bugs) and gets rid of the infection.

Amoxicillin is sometimes used to get rid of Helicobacter pylori, an infection often found in people with stomach ulcers.

It is not effective against infections caused by viruses.

Amoxicillin belongs to a group of antibiotics called penicillins. In New Zealand amoxicillin is available as capsules and liquid and can be given as an injection in the hospital.

The dose of amoxicillin will be different for different people depending on the type of infection and your age.

Adults : the usual dose in adults is 250 or 500 milligrams 3 times a day. Children : the dose for children will depend on their body weight. Your doctor will advise you how long to take amoxicillin for (usually 3 to 7 days). Always take your amoxicillin exactly as your doctor has told you. The pharmacy label on your medicine will tell you how much to take, how often to take it and any special instructions.

Capsules : swallow the capsules with a glass of water or milk.

Measure the right amount using an oral syringe or medicine spoon. Do not use a kitchen spoon as it will not give you the right amount. Read more: Tips on how to give medicines to babies and children. Try to space the doses evenly throughout the day, such as the first thing in the morning, early afternoon and at bedtime. Ideally these times should be at least 4 hours apart.

If you forget to take your dose at the correct time, take one as soon as you remember. Try to take the correct number of doses each day, leaving at least 4 hours between doses. Do not take 2 doses at the same time to make up for a forgotten dose.

If you are sick (vomit) less than 30 minutes after having a dose of amoxicillin, take the same dose again.

But, i f you are sick (vomit) and it is more than 30 minutes after having a dose of amoxicillin, you do not need to take another dose. Store your capsules in a cool, dry place, away from direct heat and light.

if you have been given liquid medicine, this will have been made up by the pharmacy and you may need to keep it in the fridge – check the instructions on the bottle. It is best to take the whole course of antibiotics for the number of days your doctor has told you to. Do not stop taking it, even if you feel your infection has cleared up.

Have ever had an allergic reaction to a medicine, especially a penicillin antibiotic?

Do you have problems with the way your kidneys work? This includes any medicines you are taking that you can buy without a prescription, as well as herbal and complementary medicines. If so, it’s important that you tell your doctor or pharmacist before you start amoxicillin.

Sometimes a medicine isn’t suitable for a person with certain conditions, or it can only be

used

Often side effects improve as your body gets used to the new medicine.

Amoxicillin may interact with some medicines and herbal supplements, so check with your doctor or pharmacist before starting a moxicillin.

If you are taking the contraceptive pill, its effectiveness can be reduced if you have a bout of being sick (vomiting) or diarrhoea that lasts for more than 24 hours.

If this happens, ask your doctor or pharmacist for advice about contraception over the following few days.

The following links have more information on amoxicillin. New Zealand Formulary Patient Information: References. Amoxicillin New Zealand Formulary Antibiotics – choices for common infections BPAC, NZ, 2017. The Maori Pharmacists’ Association have a free phone line to help answer any questions whanau may have about their medicines.

About co-amoxiclav Key facts Who can and can't take co-amoxiclav How and when to take it Side effects

How

It is used in adults and children to treat: middle ear and sinus infections throat or lung respiratory tract infections urinary tract infections skin and soft tissue infections dental infections joint and bone infections.

It's also given by injection, but this is usually only done in a hospital. For most infections, you'll start to feel better within a few days.

The most common side effects of co-amoxiclav are diarrhoea, thrush and feeling or being sick. This is not permanent and brushing your teeth will remove any stains. Co-amoxiclav is also called by the brand name Augmentin. Co-amoxiclav can be taken by adults, including pregnant and breastfeeding women.

To make sure co-amoxiclav is safe for you, tell your doctor if you: have had an allergic reaction to amoxicillin, clavulanic acid, penicillin or any of the other ingredients have had a severe allergic reaction to any other antibiotic.

This can include a skin rash or swelling of the face and throat have ever had liver problems or jaundice (yellowing of

the

The doctor will use your child's weight to work out the right dose for them.

Try to space the doses out evenly throughout the day, at least 4 hours apart.

Carry on taking

this

If you find tablets hard to swallow, you can break them in half. There is a line down the middle to make them easier to break.

Take both pieces at the same time, swallowing one after the other.

If you are taking co-amoxiclav as a liquid, shake the bottle well before using. The medicine will come with a plastic syringe or spoon to help you measure out the right dose.

If you do not have one, ask your pharmacist for one. Do not use a kitchen teaspoon as it will not give the right amount.

If you forget to take a dose, take it as soon as you remember, then wait about 4 hours before taking your next one. However, if it's nearly time for your next dose just leave out the missed one and take your next dose as normal.

Never take an extra dose to make up for a forgotten one.

If you forget doses often, it may help to set an alarm to remind you.

You could ask your pharmacist for advice on other ways to remember your medicines.

Accidently taking 1 extra dose of co-amoxiclav is unlikely to harm you. Signs of taking too much co-amoxiclav might include an upset

stomach

Speak to your pharmacist or doctor as soon as possible if you take 2 extra doses or more.

Like all medicines, co-amoxiclav can cause side effects, although not everyone gets them. These common side effects happen in around 1 in 10 people. Keep taking the medicine but talk to your doctor or pharmacist if these side effects bother you or don't go away: diarrhoea itching, redness and discomfort in or around your mouth, armpits, vagina, penis or groin area – these are symptoms of thrush (a yeast infection) feeling or being sick (nausea or vomiting), especially when taking high doses of co-amoxiclav. Serious side effects are not common and happen in less than 1 in 100 people. Tell a doctor straight away if you have: a skin rash which may blister, and looks like small targets (central dark spots surrounded by a paler area, with a dark ring around the edge – these are signs of a skin reaction called erythema multiforme) watery diarrhoea – usually with blood and mucus stomach pain, possibly with a high temperature – these are signs of inflammation of the large intestines pale poo with dark pee, yellowing of the skin or the whites of your eyes – these are warning signs of liver or gall bladder problems.

This can happen even after you have finished taking this medicine.

When you’re pregnant, you share a lot with your growing baby. Oxygen and nourishment pass from you to your baby through the placenta, an organ in your uterus that acts as your baby’s lifeline.

Most drugs may be safe for you, but there’s a chance that some may harm your developing baby. Still, it’s not uncommon to need medications during pregnancy. If you get a bacterial infection while you’re pregnant, you may need to take an antibiotic, such as amoxicillin, to treat the infection. Amoxicillin is a prescription drug that’s used to treat certain kinds of bacterial infections. These include pneumonia, bronchitis, and urinary tract infections (UTI). They also include skin, throat, and ear infections.

This drug works by stopping the growth of harmful bacteria in your body.

Here’s what you need to know about the safety of amoxicillin during pregnancy. You’ll also find possible side effects the drug may cause, as well as how an infection can affect your pregnancy. Amoxicillin is in the penicillin family of antibiotics. Some antibiotics are safe to take during pregnancy, while others are not. Amoxicillin is considered a pregnancy category B drug by the U.S. That means it’s considered safe to take while pregnant. The FDA assigned this category to help doctors understand whether or not amoxicillin can cause birth defects when taken by pregnant women.

In animal studies, there were no reports of harm to developing babies from amoxicillin.

This drug is considered low risk if a woman takes it in any trimester of pregnancy. There are other antibiotics that are also considered safe to take during pregnancy. They also include other drugs in the same class as amoxicillin, such as ampicillin or penicillin. Your doctor will decide which antibiotic is best and safest for you to take during your pregnancy. You should start to feel better a few days after you start treatment with amoxicillin. You should not skip doses or stop taking the drug if you feel better.

Make sure you finish your full course of treatment.

If you don’t take it as directed, your infection may come back.

That means that the drug may not work to treat a similar infection you may have in the future. The most common side effects of amoxicillin include the following: vomiting upset stomach diarrhea.

If this drug upsets your stomach, try taking it with food. Also be sure to take it with a full glass of water.

In some cases, amoxicillin can cause more serious side effects. Tell your doctor right away if you have any severe side effects. These include: allergic reactions bloody or watery diarrhea lack of energy unusual bleeding or bruising seizures unusual tiredness yellowing of your skin or the white part of your eyes.

If you have watery diarrhea two or three times or more per day for at least two days, or if you have stomach cramping, call your doctor right away.